Target name

P08473: Neprilysin


  Protein function

Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (PubMed:15283675, PubMed:8168535). Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (PubMed:17101991). Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (PubMed:15283675). Involved in the degradation of atrial natriuretic factor (ANF) (PubMed:2531377, PubMed:2972276). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (PubMed:20876573).

  Database links

Uniprot primary ID P08473
PDB ID 2QPJ 1DL9 1DMT 1QVD 2YB9 4CTH 1R1J 1R1H 1R1I 1Y8J
DrugBank ID DB00616 DB06655
BioGrid ID 110455
GuidetoPHARMACOLOGY ID 1611
PharmGKB ID PA30864
KEGG ID hsa:4311
DIP ID
STRING ID 9606.ENSP00000353679
IntAct ID P08473
DMDM 128062
BRENDA 3.4.24.11
Reactome R-HSA-2022377
SignaLink
BioCyc
Entrez Gene (Gene ID) 4311
BindingDB P08473

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.906 0.005 0.928 0.005 0.917 0.005 0.915 0.005 0.970 0.000 0.832 0.006 Download
Estate fingerprints 0.974 0.005 0.936 0.003 0.955 0.005 0.959 0.003 0.990 0.000 0.911 0.003 Download
MACCS fingerprints 0.952 0.004 0.936 0.000 0.944 0.005 0.947 0.005 0.980 0.000 0.889 0.003 Download
Daylight fingerprints 0.822 0.004 0.798 0.000 0.810 0.000 0.811 0.003 0.868 0.004 0.620 0.005 Download
ECFP2 fingerprints 0.981 0.003 0.959 0.004 0.970 0.000 0.970 0.000 1.000 0.000 0.941 0.003 Download
ECFP4 fingerprints 0.980 0.000 0.964 0.005 0.972 0.004 0.972 0.004 1.000 0.000 0.950 0.000 Download
ECFP6 fingerprints 0.970 0.000 0.988 0.003 0.979 0.003 0.979 0.003 1.000 0.000 0.951 0.003 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
 E-mail: biomed@csu.edu.cn