TargetNet
  Target name

P08483: Muscarinic acetylcholine receptor M3

  Protein function

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

  Database links
Uniprot primary ID P08483
PDB ID 2AMK 4U16 4DAJ 4U14 4U15
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 15
PharmGKB ID
KEGG ID rno:24260
DIP ID
STRING ID 10116.ENSRNOP00000067435
IntAct ID P08483
DMDM
BRENDA
Reactome R-RNO-390648 R-RNO-399997 R-RNO-416476
SignaLink
BioCyc
Entrez Gene (Gene ID) 24260
BindingDB P08483
  Model Performance Metrics
Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.917 0.005 0.863 0.003 0.890 0.000 0.891 0.003 0.932 0.004 0.781 0.003 Download
Estate fingerprints 0.948 0.004 0.742 0.007 0.845 0.005 0.859 0.003 0.910 0.000 0.703 0.007 Download
MACCS fingerprints 0.944 0.007 0.780 0.010 0.862 0.004 0.874 0.005 0.940 0.000 0.735 0.011 Download
Daylight fingerprints 0.852 0.011 0.864 0.009 0.858 0.008 0.858 0.008 0.915 0.008 0.720 0.018 Download
ECFP2 fingerprints 0.891 0.003 0.921 0.010 0.906 0.007 0.903 0.007 0.960 0.000 0.810 0.014 Download
ECFP4 fingerprints 0.886 0.007 0.964 0.007 0.925 0.005 0.924 0.007 0.969 0.003 0.854 0.007 Download
ECFP6 fingerprints 0.844 0.010 0.996 0.005 0.920 0.005 0.914 0.005 0.968 0.004 0.850 0.009 Download
  Download datasets
Positive dataset Negative dataset

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 E-mail: biomed@csu.edu.cn