Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS.
Uniprot primary ID | P08631 |
PDB ID | 2HK5 2HCK 3VS6 3VS7 3VS4 3VS5 3VS2 3VS3 3VS0 3VS1 3RBB 5HCK 2C0I 3VRZ 2C0O 3REA 3REB 2OI3 4HCK 3HCK 2C0T 3VRY 1BU1 1QCF 4U5W 4ORZ 1AD5 3NHN 4LUE 4LUD 2OJ2 |
DrugBank ID | DB06616 |
BioGrid ID | 109305 |
GuidetoPHARMACOLOGY ID | 2032 |
PharmGKB ID | PA29216 |
KEGG ID | hsa:3055 |
DIP ID | DIP-1051N |
STRING ID | 9606.ENSP00000365012 |
IntAct ID | P08631 |
DMDM | 20141296 |
BRENDA | 2.7.10.2 |
Reactome | R-HSA-912631 R-HSA-2029481 R-HSA-164944 |
SignaLink | P08631 |
BioCyc | |
Entrez Gene (Gene ID) | 3055 |
BindingDB | P08631 |
Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FP2 fingerprints | 0.813 | 0.005 | 0.959 | 0.007 | 0.886 | 0.005 | 0.879 | 0.003 | 0.960 | 0.000 | 0.782 | 0.009 | Download |
Estate fingerprints | 0.812 | 0.009 | 0.800 | 0.007 | 0.806 | 0.005 | 0.806 | 0.005 | 0.902 | 0.004 | 0.609 | 0.011 | Download |
MACCS fingerprints | 0.810 | 0.011 | 0.848 | 0.004 | 0.829 | 0.006 | 0.825 | 0.010 | 0.938 | 0.004 | 0.656 | 0.014 | Download |
Daylight fingerprints | 0.753 | 0.011 | 0.927 | 0.008 | 0.840 | 0.007 | 0.828 | 0.008 | 0.927 | 0.005 | 0.693 | 0.009 | Download |
ECFP2 fingerprints | 0.868 | 0.008 | 0.900 | 0.005 | 0.884 | 0.005 | 0.884 | 0.005 | 0.960 | 0.000 | 0.776 | 0.008 | Download |
ECFP4 fingerprints | 0.784 | 0.005 | 0.976 | 0.000 | 0.880 | 0.000 | 0.869 | 0.003 | 0.961 | 0.003 | 0.779 | 0.003 | Download |
ECFP6 fingerprints | 0.716 | 0.005 | 0.990 | 0.004 | 0.853 | 0.005 | 0.829 | 0.007 | 0.963 | 0.005 | 0.736 | 0.013 | Download |
Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn