Target name

P08631: Tyrosine-protein kinase HCK


  Protein function

Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS.

  Database links

Uniprot primary ID P08631
PDB ID 2HK5 2HCK 3VS6 3VS7 3VS4 3VS5 3VS2 3VS3 3VS0 3VS1 3RBB 5HCK 2C0I 3VRZ 2C0O 3REA 3REB 2OI3 4HCK 3HCK 2C0T 3VRY 1BU1 1QCF 4U5W 4ORZ 1AD5 3NHN 4LUE 4LUD 2OJ2
DrugBank ID DB06616
BioGrid ID 109305
GuidetoPHARMACOLOGY ID 2032
PharmGKB ID PA29216
KEGG ID hsa:3055
DIP ID DIP-1051N
STRING ID 9606.ENSP00000365012
IntAct ID P08631
DMDM 20141296
BRENDA 2.7.10.2
Reactome R-HSA-912631 R-HSA-2029481 R-HSA-164944
SignaLink P08631
BioCyc
Entrez Gene (Gene ID) 3055
BindingDB P08631

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.813 0.005 0.959 0.007 0.886 0.005 0.879 0.003 0.960 0.000 0.782 0.009 Download
Estate fingerprints 0.812 0.009 0.800 0.007 0.806 0.005 0.806 0.005 0.902 0.004 0.609 0.011 Download
MACCS fingerprints 0.810 0.011 0.848 0.004 0.829 0.006 0.825 0.010 0.938 0.004 0.656 0.014 Download
Daylight fingerprints 0.753 0.011 0.927 0.008 0.840 0.007 0.828 0.008 0.927 0.005 0.693 0.009 Download
ECFP2 fingerprints 0.868 0.008 0.900 0.005 0.884 0.005 0.884 0.005 0.960 0.000 0.776 0.008 Download
ECFP4 fingerprints 0.784 0.005 0.976 0.000 0.880 0.000 0.869 0.003 0.961 0.003 0.779 0.003 Download
ECFP6 fingerprints 0.716 0.005 0.990 0.004 0.853 0.005 0.829 0.007 0.963 0.005 0.736 0.013 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
 E-mail: biomed@csu.edu.cn