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E-mail: biomed@csu.edu.cn
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Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium.
| Uniprot primary ID | P08709 |
| PDB ID | 2PUQ 1WUN 4JYV 1WQV 1DAN 2B8O 4ISH 4ISI 1WSS 4X8S 1YGC 3ELA 4X8V 1QFK 1F7M 4NGA 1F7E 1FFM 1O5D 1JBU 2ZP0 1W7X 1KLJ 1Z6J 1WV7 2BZ6 1KLI 4ZXX 4ZXY 1CVW 4JZD 4JZE 4JZF 1WTG 2AEI 4X8U 1J9C 2C4F 2AER 4JYU 1FF7 1W8B 2F9B 4X8T 2B7D 2FLR 4YT6 2ZWL 1BF9 1W2K 1W0Y |
| DrugBank ID | DB00100 DB00170 DB00036 |
| BioGrid ID | 108453 |
| GuidetoPHARMACOLOGY ID | 2363 |
| PharmGKB ID | PA160 |
| KEGG ID | hsa:2155 |
| DIP ID | DIP-6135N |
| STRING ID | 9606.ENSP00000364731 |
| IntAct ID | P08709 |
| DMDM | 119766 |
| BRENDA | 3.4.21.21 |
| Reactome | R-HSA-159740 R-HSA-1368108 R-HSA-140834 R-HSA-159763 R-HSA-159782 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 2155 |
| BindingDB | P08709 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.900 | 0.000 | 0.974 | 0.000 | 0.937 | 0.005 | 0.932 | 0.004 | 0.980 | 0.000 | 0.873 | 0.005 | Download |
| Estate fingerprints | 0.929 | 0.003 | 0.927 | 0.004 | 0.928 | 0.004 | 0.929 | 0.003 | 0.980 | 0.000 | 0.853 | 0.005 | Download |
| MACCS fingerprints | 0.930 | 0.000 | 0.930 | 0.005 | 0.930 | 0.000 | 0.930 | 0.000 | 0.980 | 0.000 | 0.858 | 0.004 | Download |
| Daylight fingerprints | 0.793 | 0.007 | 0.957 | 0.004 | 0.875 | 0.007 | 0.863 | 0.007 | 0.920 | 0.000 | 0.757 | 0.008 | Download |
| ECFP2 fingerprints | 0.990 | 0.000 | 0.950 | 0.005 | 0.970 | 0.000 | 0.970 | 0.000 | 0.990 | 0.000 | 0.939 | 0.003 | Download |
| ECFP4 fingerprints | 0.980 | 0.000 | 0.978 | 0.003 | 0.979 | 0.003 | 0.979 | 0.003 | 0.995 | 0.005 | 0.951 | 0.003 | Download |
| ECFP6 fingerprints | 0.978 | 0.004 | 0.982 | 0.000 | 0.980 | 0.000 | 0.980 | 0.000 | 1.000 | 0.000 | 0.960 | 0.000 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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