Target name

P08709: Coagulation factor VII


  Protein function

Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium.

  Database links

Uniprot primary ID P08709
PDB ID 2PUQ 1WUN 4JYV 1WQV 1DAN 2B8O 4ISH 4ISI 1WSS 4X8S 1YGC 3ELA 4X8V 1QFK 1F7M 4NGA 1F7E 1FFM 1O5D 1JBU 2ZP0 1W7X 1KLJ 1Z6J 1WV7 2BZ6 1KLI 4ZXX 4ZXY 1CVW 4JZD 4JZE 4JZF 1WTG 2AEI 4X8U 1J9C 2C4F 2AER 4JYU 1FF7 1W8B 2F9B 4X8T 2B7D 2FLR 4YT6 2ZWL 1BF9 1W2K 1W0Y
DrugBank ID DB00100 DB00170 DB00036
BioGrid ID 108453
GuidetoPHARMACOLOGY ID 2363
PharmGKB ID PA160
KEGG ID hsa:2155
DIP ID DIP-6135N
STRING ID 9606.ENSP00000364731
IntAct ID P08709
DMDM 119766
BRENDA 3.4.21.21
Reactome R-HSA-159740 R-HSA-1368108 R-HSA-140834 R-HSA-159763 R-HSA-159782
SignaLink
BioCyc
Entrez Gene (Gene ID) 2155
BindingDB P08709

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.900 0.000 0.974 0.000 0.937 0.005 0.932 0.004 0.980 0.000 0.873 0.005 Download
Estate fingerprints 0.929 0.003 0.927 0.004 0.928 0.004 0.929 0.003 0.980 0.000 0.853 0.005 Download
MACCS fingerprints 0.930 0.000 0.930 0.005 0.930 0.000 0.930 0.000 0.980 0.000 0.858 0.004 Download
Daylight fingerprints 0.793 0.007 0.957 0.004 0.875 0.007 0.863 0.007 0.920 0.000 0.757 0.008 Download
ECFP2 fingerprints 0.990 0.000 0.950 0.005 0.970 0.000 0.970 0.000 0.990 0.000 0.939 0.003 Download
ECFP4 fingerprints 0.980 0.000 0.978 0.003 0.979 0.003 0.979 0.003 0.995 0.005 0.951 0.003 Download
ECFP6 fingerprints 0.978 0.004 0.982 0.000 0.980 0.000 0.980 0.000 1.000 0.000 0.960 0.000 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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