G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release of CRH that then regulates the release of corticosterone. Plays a role in the regulation of appetite and feeding behavior, responses to anxiogenic stimuli and stress. Plays a role in insulin sensitivity and glucose homeostasis.
Uniprot primary ID | P08909 |
PDB ID | 2MHO |
DrugBank ID | DB00540 DB00726 |
BioGrid ID | |
GuidetoPHARMACOLOGY ID | 8 |
PharmGKB ID | |
KEGG ID | rno:25187 |
DIP ID | |
STRING ID | 10116.ENSRNOP00000060345 |
IntAct ID | |
DMDM | |
BRENDA | |
Reactome | |
SignaLink | |
BioCyc | |
Entrez Gene (Gene ID) | 25187 |
BindingDB | P08909 |
Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FP2 fingerprints | 0.843 | 0.007 | 0.813 | 0.004 | 0.828 | 0.004 | 0.831 | 0.003 | 0.900 | 0.000 | 0.657 | 0.007 | Download |
Estate fingerprints | 0.768 | 0.004 | 0.788 | 0.004 | 0.778 | 0.004 | 0.777 | 0.005 | 0.861 | 0.003 | 0.558 | 0.004 | Download |
MACCS fingerprints | 0.811 | 0.003 | 0.771 | 0.003 | 0.791 | 0.003 | 0.797 | 0.005 | 0.880 | 0.000 | 0.583 | 0.008 | Download |
Daylight fingerprints | 0.594 | 0.007 | 0.784 | 0.004 | 0.689 | 0.003 | 0.659 | 0.003 | 0.770 | 0.000 | 0.387 | 0.007 | Download |
ECFP2 fingerprints | 0.936 | 0.005 | 0.844 | 0.005 | 0.890 | 0.000 | 0.895 | 0.005 | 0.960 | 0.000 | 0.784 | 0.005 | Download |
ECFP4 fingerprints | 0.929 | 0.006 | 0.905 | 0.005 | 0.917 | 0.005 | 0.919 | 0.003 | 0.970 | 0.000 | 0.834 | 0.007 | Download |
ECFP6 fingerprints | 0.901 | 0.003 | 0.919 | 0.008 | 0.910 | 0.005 | 0.910 | 0.000 | 0.970 | 0.000 | 0.818 | 0.006 | Download |
Positive dataset | Negative dataset |
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