Target name

P08909: 5-hydroxytryptamine receptor 2C


  Protein function

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release of CRH that then regulates the release of corticosterone. Plays a role in the regulation of appetite and feeding behavior, responses to anxiogenic stimuli and stress. Plays a role in insulin sensitivity and glucose homeostasis.

  Database links

Uniprot primary ID P08909
PDB ID 2MHO
DrugBank ID DB00540 DB00726
BioGrid ID
GuidetoPHARMACOLOGY ID 8
PharmGKB ID
KEGG ID rno:25187
DIP ID
STRING ID 10116.ENSRNOP00000060345
IntAct ID
DMDM
BRENDA
Reactome
SignaLink
BioCyc
Entrez Gene (Gene ID) 25187
BindingDB P08909

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.843 0.007 0.813 0.004 0.828 0.004 0.831 0.003 0.900 0.000 0.657 0.007 Download
Estate fingerprints 0.768 0.004 0.788 0.004 0.778 0.004 0.777 0.005 0.861 0.003 0.558 0.004 Download
MACCS fingerprints 0.811 0.003 0.771 0.003 0.791 0.003 0.797 0.005 0.880 0.000 0.583 0.008 Download
Daylight fingerprints 0.594 0.007 0.784 0.004 0.689 0.003 0.659 0.003 0.770 0.000 0.387 0.007 Download
ECFP2 fingerprints 0.936 0.005 0.844 0.005 0.890 0.000 0.895 0.005 0.960 0.000 0.784 0.005 Download
ECFP4 fingerprints 0.929 0.006 0.905 0.005 0.917 0.005 0.919 0.003 0.970 0.000 0.834 0.007 Download
ECFP6 fingerprints 0.901 0.003 0.919 0.008 0.910 0.005 0.910 0.000 0.970 0.000 0.818 0.006 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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