Target name

P08912: Muscarinic acetylcholine receptor M5


  Protein function

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

  Database links

Uniprot primary ID P08912
PDB ID
DrugBank ID DB00777 DB01142 DB00496 DB00321 DB01224 DB00934 DB00420
BioGrid ID
GuidetoPHARMACOLOGY ID 17
PharmGKB ID PA26486
KEGG ID hsa:1133
DIP ID
STRING ID 9606.ENSP00000372750
IntAct ID
DMDM 543761
BRENDA
Reactome R-HSA-390648 R-HSA-416476
SignaLink
BioCyc
Entrez Gene (Gene ID) 1133
BindingDB P08912

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.851 0.009 0.843 0.007 0.847 0.008 0.849 0.007 0.920 0.000 0.697 0.008 Download
Estate fingerprints 0.860 0.007 0.794 0.005 0.827 0.005 0.835 0.005 0.899 0.003 0.657 0.009 Download
MACCS fingerprints 0.860 0.007 0.808 0.008 0.834 0.005 0.839 0.006 0.900 0.000 0.668 0.009 Download
Daylight fingerprints 0.741 0.011 0.827 0.006 0.784 0.005 0.774 0.005 0.848 0.004 0.565 0.012 Download
ECFP2 fingerprints 0.920 0.007 0.872 0.006 0.896 0.005 0.899 0.003 0.960 0.000 0.792 0.006 Download
ECFP4 fingerprints 0.903 0.007 0.939 0.006 0.921 0.003 0.921 0.003 0.970 0.000 0.849 0.006 Download
ECFP6 fingerprints 0.838 0.012 0.974 0.003 0.906 0.007 0.897 0.008 0.960 0.000 0.820 0.012 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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