Target name

P08913: Alpha-2A adrenergic receptor


  Protein function

Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol.

  Database links

Uniprot primary ID P08913
PDB ID 1HOF 1HOD 1HLL 1HO9
DrugBank ID DB00751 DB06148 DB01142 DB01049 DB01624 DB00852 DB00246
BioGrid ID 106659
GuidetoPHARMACOLOGY ID 25
PharmGKB ID PA35
KEGG ID hsa:150
DIP ID DIP-61452N
STRING ID 9606.ENSP00000280155
IntAct ID P08913
DMDM 1351829
BRENDA
Reactome R-HSA-400042 R-HSA-418594 R-HSA-418597 R-HSA-390696 R-HSA-392023
SignaLink P08913
BioCyc
Entrez Gene (Gene ID) 150
BindingDB P08913

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.706 0.007 0.854 0.005 0.780 0.000 0.764 0.005 0.871 0.003 0.566 0.005 Download
Estate fingerprints 0.720 0.008 0.762 0.005 0.741 0.003 0.736 0.005 0.830 0.000 0.486 0.008 Download
MACCS fingerprints 0.779 0.006 0.743 0.005 0.761 0.003 0.763 0.005 0.850 0.000 0.518 0.010 Download
Daylight fingerprints 0.610 0.000 0.752 0.005 0.681 0.003 0.659 0.003 0.739 0.003 0.368 0.004 Download
ECFP2 fingerprints 0.878 0.004 0.828 0.003 0.853 0.005 0.859 0.003 0.940 0.000 0.710 0.005 Download
ECFP4 fingerprints 0.883 0.005 0.907 0.005 0.895 0.005 0.892 0.004 0.953 0.005 0.785 0.005 Download
ECFP6 fingerprints 0.853 0.007 0.921 0.005 0.887 0.007 0.883 0.005 0.950 0.000 0.775 0.008 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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 E-mail: biomed@csu.edu.cn