Target name

P09237: Matrilysin


  Protein function

Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase.

  Database links

Uniprot primary ID P09237
PDB ID 1MMP 2DDY 1MMQ 2Y6D 1MMR 2Y6C
DrugBank ID DB00786
BioGrid ID 110459
GuidetoPHARMACOLOGY ID 1631
PharmGKB ID PA30887
KEGG ID hsa:4316
DIP ID
STRING ID 9606.ENSP00000260227
IntAct ID P09237
DMDM 116861
BRENDA 3.4.24.23
Reactome R-HSA-1592389 R-HSA-2022090 R-HSA-1474228 R-HSA-1442490
SignaLink
BioCyc
Entrez Gene (Gene ID) 4316
BindingDB P09237

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.793 0.007 0.917 0.004 0.855 0.005 0.845 0.005 0.950 0.000 0.715 0.005 Download
Estate fingerprints 0.888 0.004 0.832 0.005 0.860 0.000 0.863 0.005 0.944 0.005 0.718 0.004 Download
MACCS fingerprints 0.870 0.000 0.872 0.003 0.871 0.003 0.870 0.000 0.950 0.000 0.746 0.005 Download
Daylight fingerprints 0.709 0.007 0.959 0.000 0.834 0.005 0.809 0.006 0.960 0.000 0.688 0.006 Download
ECFP2 fingerprints 0.973 0.005 0.949 0.000 0.961 0.003 0.961 0.003 0.990 0.000 0.926 0.005 Download
ECFP4 fingerprints 0.971 0.003 0.969 0.000 0.970 0.000 0.970 0.000 0.990 0.000 0.946 0.005 Download
ECFP6 fingerprints 0.968 0.004 0.974 0.000 0.971 0.003 0.971 0.003 0.990 0.000 0.946 0.005 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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