After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions.
| Uniprot primary ID | P09483 |
| PDB ID | 1OLE |
| DrugBank ID | |
| BioGrid ID | |
| GuidetoPHARMACOLOGY ID | 465 |
| PharmGKB ID | |
| KEGG ID | rno:25590 |
| DIP ID | |
| STRING ID | 10116.ENSRNOP00000009041 |
| IntAct ID | P09483 |
| DMDM | |
| BRENDA | |
| Reactome | |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 25590 |
| BindingDB | P09483 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.912 | 0.008 | 0.864 | 0.005 | 0.888 | 0.004 | 0.889 | 0.003 | 0.960 | 0.000 | 0.773 | 0.008 | Download |
| Estate fingerprints | 0.918 | 0.009 | 0.822 | 0.006 | 0.870 | 0.007 | 0.874 | 0.007 | 0.930 | 0.000 | 0.744 | 0.013 | Download |
| MACCS fingerprints | 0.880 | 0.011 | 0.868 | 0.005 | 0.874 | 0.007 | 0.874 | 0.007 | 0.940 | 0.000 | 0.750 | 0.012 | Download |
| Daylight fingerprints | 0.857 | 0.009 | 0.835 | 0.004 | 0.846 | 0.005 | 0.846 | 0.005 | 0.884 | 0.005 | 0.695 | 0.007 | Download |
| ECFP2 fingerprints | 0.990 | 0.000 | 0.894 | 0.005 | 0.942 | 0.004 | 0.947 | 0.005 | 0.996 | 0.005 | 0.891 | 0.006 | Download |
| ECFP4 fingerprints | 0.984 | 0.008 | 0.940 | 0.005 | 0.962 | 0.004 | 0.962 | 0.004 | 0.997 | 0.005 | 0.927 | 0.008 | Download |
| ECFP6 fingerprints | 0.970 | 0.000 | 0.970 | 0.004 | 0.970 | 0.000 | 0.970 | 0.000 | 0.988 | 0.004 | 0.938 | 0.004 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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