Target name

P09619: Platelet-derived growth factor receptor beta


  Protein function

Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites. Required for normal development of the cardiovascular system. Required for normal recruitment of pericytes (mesangial cells) in the kidney glomerulus, and for normal formation of a branched network of capillaries in kidney glomeruli. Promotes rearrangement of the actin cytoskeleton and the formation of membrane ruffles. Binding of its cognate ligands - homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFD -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PLCG1, PIK3R1, PTPN11, RASA1/GAP, CBL, SHC1 and NCK1. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to the activation of the AKT1 signaling pathway. Phosphorylation of SHC1, or of the C-terminus of PTPN11, creates a binding site for GRB2, resulting in the activation of HRAS, RAF1 and down-stream MAP kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation and activation of SRC family kinases. Promotes phosphorylation of PDCD6IP/ALIX and STAM. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor.

  Database links

Uniprot primary ID P09619
PDB ID 3MJG 2L6W 1LWP 1H9O 1GQ5 2PLD 2PLE 1SHA
DrugBank ID DB00619 DB00102 DB01268 DB06589 DB08896 DB00398 DB01254
BioGrid ID 111185
GuidetoPHARMACOLOGY ID 1804
PharmGKB ID PA33148
KEGG ID hsa:5159
DIP ID DIP-558N
STRING ID 9606.ENSP00000261799
IntAct ID P09619
DMDM 129890
BRENDA 2.7.10.1
Reactome R-HSA-186797 R-HSA-2219530 R-HSA-186763 R-HSA-1257604 R-HSA-5673001
SignaLink P09619
BioCyc
Entrez Gene (Gene ID) 5159
BindingDB P09619

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.881 0.003 0.897 0.003 0.889 0.003 0.889 0.003 0.940 0.000 0.772 0.004 Download
Estate fingerprints 0.829 0.003 0.787 0.005 0.808 0.004 0.810 0.000 0.870 0.000 0.614 0.005 Download
MACCS fingerprints 0.841 0.003 0.739 0.004 0.790 0.000 0.800 0.000 0.880 0.000 0.583 0.005 Download
Daylight fingerprints 0.703 0.005 0.945 0.005 0.824 0.005 0.800 0.000 0.920 0.000 0.669 0.003 Download
ECFP2 fingerprints 0.934 0.005 0.884 0.003 0.909 0.003 0.910 0.000 0.960 0.000 0.813 0.005 Download
ECFP4 fingerprints 0.900 0.000 0.946 0.000 0.923 0.005 0.921 0.003 0.970 0.000 0.850 0.005 Download
ECFP6 fingerprints 0.851 0.003 0.973 0.000 0.912 0.004 0.910 0.000 0.970 0.000 0.832 0.004 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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