Target name

P09874: Poly [ADP-ribose] polymerase 1


  Protein function

Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Required for PARP9 and DTX3L recruitment to DNA damage sites. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites.

  Database links

Uniprot primary ID P09874
PDB ID 4L6S 5A00 2JVN 2L31 4R5W 3GN7 4DQY 1UK0 2RIQ 2COK 1WOK 4OPX 2RD6 3L3L 3L3M 3OD8 2CR9 2RCW 2DMJ 4HHY 4HHZ 2L30 4ZZZ 4UXB 3ODE 4R6E 3ODA 4PJT 3GJW 4GV7 2CS2 1UK1 4AV1 4UND 4OQA 4OQB 3ODC
DrugBank ID DB09074
BioGrid ID 106652
GuidetoPHARMACOLOGY ID 2771
PharmGKB ID PA32
KEGG ID hsa:142
DIP ID DIP-38N
STRING ID 9606.ENSP00000355759
IntAct ID P09874
DMDM 130781
BRENDA 2.4.2.30
Reactome R-HSA-110362 R-HSA-2173795 R-HSA-3108214
SignaLink P09874
BioCyc
Entrez Gene (Gene ID) 142
BindingDB P09874

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.910 0.000 0.878 0.003 0.894 0.005 0.900 0.000 0.951 0.003 0.790 0.000 Download
Estate fingerprints 0.826 0.005 0.812 0.000 0.819 0.003 0.820 0.000 0.910 0.000 0.635 0.005 Download
MACCS fingerprints 0.918 0.004 0.824 0.000 0.871 0.003 0.880 0.000 0.940 0.000 0.748 0.004 Download
Daylight fingerprints 0.801 0.003 0.939 0.000 0.870 0.000 0.860 0.000 0.930 0.000 0.749 0.003 Download
ECFP2 fingerprints 0.970 0.000 0.928 0.000 0.949 0.003 0.950 0.000 0.990 0.000 0.892 0.004 Download
ECFP4 fingerprints 0.970 0.000 0.970 0.000 0.970 0.000 0.970 0.000 0.990 0.000 0.941 0.003 Download
ECFP6 fingerprints 0.950 0.000 0.990 0.000 0.970 0.000 0.970 0.000 0.990 0.000 0.935 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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