Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes.
| Uniprot primary ID | P09917 |
| PDB ID | 3V98 3V99 3V92 3O8Y 2ABV |
| DrugBank ID | DB00471 DB01014 DB00795 DB00744 DB00586 DB00939 DB00163 |
| BioGrid ID | 106741 |
| GuidetoPHARMACOLOGY ID | 1385 |
| PharmGKB ID | PA46 |
| KEGG ID | hsa:240 |
| DIP ID | DIP-30950N |
| STRING ID | 9606.ENSP00000363512 |
| IntAct ID | P09917 |
| DMDM | 126407 |
| BRENDA | 1.13.11.34 |
| Reactome | R-HSA-2142691 R-HSA-2142688 R-HSA-2142700 |
| SignaLink | |
| BioCyc | MetaCyc:HS00336-MONOMER |
| Entrez Gene (Gene ID) | 240 |
| BindingDB | P09917 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.790 | 0.000 | 0.850 | 0.003 | 0.820 | 0.000 | 0.810 | 0.000 | 0.900 | 0.000 | 0.638 | 0.004 | Download |
| Estate fingerprints | 0.778 | 0.004 | 0.776 | 0.000 | 0.777 | 0.005 | 0.777 | 0.005 | 0.830 | 0.000 | 0.551 | 0.003 | Download |
| MACCS fingerprints | 0.772 | 0.004 | 0.788 | 0.000 | 0.780 | 0.000 | 0.780 | 0.000 | 0.840 | 0.000 | 0.564 | 0.005 | Download |
| Daylight fingerprints | 0.682 | 0.004 | 0.776 | 0.005 | 0.729 | 0.003 | 0.715 | 0.005 | 0.790 | 0.000 | 0.459 | 0.003 | Download |
| ECFP2 fingerprints | 0.921 | 0.003 | 0.899 | 0.000 | 0.910 | 0.000 | 0.910 | 0.000 | 0.970 | 0.000 | 0.825 | 0.005 | Download |
| ECFP4 fingerprints | 0.923 | 0.005 | 0.937 | 0.000 | 0.930 | 0.000 | 0.930 | 0.000 | 0.980 | 0.000 | 0.868 | 0.004 | Download |
| ECFP6 fingerprints | 0.882 | 0.004 | 0.958 | 0.000 | 0.920 | 0.000 | 0.919 | 0.003 | 0.980 | 0.000 | 0.841 | 0.003 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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