Target name

P09917: Arachidonate 5-lipoxygenase


  Protein function

Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes.

  Database links

Uniprot primary ID P09917
PDB ID 3V98 3V99 3V92 3O8Y 2ABV
DrugBank ID DB00471 DB01014 DB00795 DB00744 DB00586 DB00939 DB00163
BioGrid ID 106741
GuidetoPHARMACOLOGY ID 1385
PharmGKB ID PA46
KEGG ID hsa:240
DIP ID DIP-30950N
STRING ID 9606.ENSP00000363512
IntAct ID P09917
DMDM 126407
BRENDA 1.13.11.34
Reactome R-HSA-2142691 R-HSA-2142688 R-HSA-2142700
SignaLink
BioCyc MetaCyc:HS00336-MONOMER
Entrez Gene (Gene ID) 240
BindingDB P09917

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.790 0.000 0.850 0.003 0.820 0.000 0.810 0.000 0.900 0.000 0.638 0.004 Download
Estate fingerprints 0.778 0.004 0.776 0.000 0.777 0.005 0.777 0.005 0.830 0.000 0.551 0.003 Download
MACCS fingerprints 0.772 0.004 0.788 0.000 0.780 0.000 0.780 0.000 0.840 0.000 0.564 0.005 Download
Daylight fingerprints 0.682 0.004 0.776 0.005 0.729 0.003 0.715 0.005 0.790 0.000 0.459 0.003 Download
ECFP2 fingerprints 0.921 0.003 0.899 0.000 0.910 0.000 0.910 0.000 0.970 0.000 0.825 0.005 Download
ECFP4 fingerprints 0.923 0.005 0.937 0.000 0.930 0.000 0.930 0.000 0.980 0.000 0.868 0.004 Download
ECFP6 fingerprints 0.882 0.004 0.958 0.000 0.920 0.000 0.919 0.003 0.980 0.000 0.841 0.003 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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