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E-mail: biomed@csu.edu.cn
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Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif.
| Uniprot primary ID | P09958 |
| PDB ID | 4RYD 4OMC 4OMD |
| DrugBank ID | |
| BioGrid ID | 111082 |
| GuidetoPHARMACOLOGY ID | 2366 |
| PharmGKB ID | PA32894 |
| KEGG ID | hsa:5045 |
| DIP ID | DIP-29904N |
| STRING ID | 9606.ENSP00000268171 |
| IntAct ID | P09958 |
| DMDM | 120611 |
| BRENDA | |
| Reactome | R-HSA-1181150 R-HSA-159782 R-HSA-1566948 R-HSA-171286 R-HSA-1442490 R-HSA-1592389 R-HSA-186797 R-HSA-2173789 R-HSA-1912420 R-HSA-5210891 R-HSA-167060 |
| SignaLink | P09958 |
| BioCyc | |
| Entrez Gene (Gene ID) | 5045 |
| BindingDB | P09958 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.918 | 0.004 | 0.980 | 0.003 | 0.949 | 0.003 | 0.948 | 0.004 | 0.990 | 0.000 | 0.898 | 0.004 | Download |
| Estate fingerprints | 0.990 | 0.000 | 0.970 | 0.000 | 0.980 | 0.000 | 0.980 | 0.000 | 0.990 | 0.000 | 0.960 | 0.000 | Download |
| MACCS fingerprints | 0.955 | 0.007 | 0.979 | 0.000 | 0.967 | 0.005 | 0.966 | 0.005 | 0.996 | 0.005 | 0.935 | 0.007 | Download |
| Daylight fingerprints | 0.898 | 0.006 | 0.826 | 0.000 | 0.862 | 0.004 | 0.870 | 0.005 | 0.902 | 0.004 | 0.727 | 0.008 | Download |
| ECFP2 fingerprints | 0.940 | 0.005 | 0.980 | 0.000 | 0.960 | 0.000 | 0.960 | 0.000 | 1.000 | 0.000 | 0.916 | 0.007 | Download |
| ECFP4 fingerprints | 0.906 | 0.005 | 0.974 | 0.000 | 0.940 | 0.000 | 0.940 | 0.000 | 0.990 | 0.000 | 0.886 | 0.005 | Download |
| ECFP6 fingerprints | 0.880 | 0.000 | 0.980 | 0.005 | 0.930 | 0.000 | 0.930 | 0.000 | 0.996 | 0.005 | 0.870 | 0.000 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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