Target name

P09958: Furin


  Protein function

Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif.

  Database links

Uniprot primary ID P09958
PDB ID 4RYD 4OMC 4OMD
DrugBank ID
BioGrid ID 111082
GuidetoPHARMACOLOGY ID 2366
PharmGKB ID PA32894
KEGG ID hsa:5045
DIP ID DIP-29904N
STRING ID 9606.ENSP00000268171
IntAct ID P09958
DMDM 120611
BRENDA
Reactome R-HSA-1181150 R-HSA-159782 R-HSA-1566948 R-HSA-171286 R-HSA-1442490 R-HSA-1592389 R-HSA-186797 R-HSA-2173789 R-HSA-1912420 R-HSA-5210891 R-HSA-167060
SignaLink P09958
BioCyc
Entrez Gene (Gene ID) 5045
BindingDB P09958

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.918 0.004 0.980 0.003 0.949 0.003 0.948 0.004 0.990 0.000 0.898 0.004 Download
Estate fingerprints 0.990 0.000 0.970 0.000 0.980 0.000 0.980 0.000 0.990 0.000 0.960 0.000 Download
MACCS fingerprints 0.955 0.007 0.979 0.000 0.967 0.005 0.966 0.005 0.996 0.005 0.935 0.007 Download
Daylight fingerprints 0.898 0.006 0.826 0.000 0.862 0.004 0.870 0.005 0.902 0.004 0.727 0.008 Download
ECFP2 fingerprints 0.940 0.005 0.980 0.000 0.960 0.000 0.960 0.000 1.000 0.000 0.916 0.007 Download
ECFP4 fingerprints 0.906 0.005 0.974 0.000 0.940 0.000 0.940 0.000 0.990 0.000 0.886 0.005 Download
ECFP6 fingerprints 0.880 0.000 0.980 0.005 0.930 0.000 0.930 0.000 0.996 0.005 0.870 0.000 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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