Target name

P09960: Leukotriene A-4 hydrolase


  Protein function

Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity.

  Database links

Uniprot primary ID P09960
PDB ID 3FH8 3FUJ 3FH7 3FH5 3FUL 3FUM 3FUN 3FUH 3FUI 2R59 3FUK 3FUD 3FUE 3FUF 3CHS 2VJ8 3B7U 3B7R 3B7S 3CHQ 1GW6 4MKT 3CHR 3FTZ 3CHP 3FTX 3FTW 3FTV 3FTU 3FTS 3B7T 4L2L 5AEN 3FTY 3CHO 1H19 4DPR 3FU5 3FU6 3FU0 4MS6 3FU3 1HS6 3U9W 1SQM 3FHE
DrugBank ID DB01197
BioGrid ID 110226
GuidetoPHARMACOLOGY ID 1395
PharmGKB ID PA24345
KEGG ID hsa:4048
DIP ID
STRING ID 9606.ENSP00000228740
IntAct ID P09960
DMDM 126353
BRENDA 3.3.2.6
Reactome R-HSA-2142691
SignaLink
BioCyc MetaCyc:HS03372-MONOMER
Entrez Gene (Gene ID) 4048
BindingDB P09960

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.960 0.000 0.920 0.005 0.940 0.000 0.940 0.000 0.980 0.000 0.877 0.005 Download
Estate fingerprints 0.917 0.009 0.829 0.005 0.873 0.005 0.877 0.005 0.940 0.000 0.749 0.009 Download
MACCS fingerprints 0.929 0.003 0.875 0.005 0.902 0.004 0.905 0.005 0.970 0.000 0.805 0.005 Download
Daylight fingerprints 0.802 0.004 0.838 0.000 0.820 0.000 0.820 0.000 0.882 0.004 0.642 0.004 Download
ECFP2 fingerprints 0.962 0.004 0.956 0.005 0.959 0.003 0.960 0.000 0.990 0.000 0.917 0.007 Download
ECFP4 fingerprints 0.968 0.004 0.970 0.004 0.969 0.003 0.969 0.003 0.999 0.003 0.935 0.005 Download
ECFP6 fingerprints 0.959 0.003 0.981 0.003 0.970 0.000 0.969 0.003 0.998 0.004 0.932 0.004 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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