Target name

P10275: Androgen receptor


  Protein function

Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.

  Database links

Uniprot primary ID P10275
PDB ID 2OZ7 4U4K 2AX8 3B65 2PNU 3B67 3B66 3B68 4OKX 3V4A 3RLL 4OKB 4OIL 2PIV 1Z95 3ZQT 4OKW 4OH6 4OH5 2HVC 2AX7 2AM9 1XQ3 2Q7J 2Q7K 2AX9 2Q7I 2AO6 2Q7L 2YHD 4OEA 4OED 2YLQ 2YLP 3L3X 3B5R 1GS4 2Z4J 2PIU 2PIT 2PIW 2PKL 2PIQ 2PIP 2PIR 2PIX 4OGH 4OLM 1T63 4OJB 3V49
DrugBank ID DB00984 DB00687 DB01185 DB00858 DB00499 DB08804 DB01395
BioGrid ID 106862
GuidetoPHARMACOLOGY ID 628
PharmGKB ID PA57
KEGG ID hsa:367
DIP ID DIP-125N
STRING ID 9606.ENSP00000363822
IntAct ID P10275
DMDM 113830
BRENDA
Reactome R-HSA-383280 R-HSA-5625886
SignaLink P10275
BioCyc
Entrez Gene (Gene ID) 367
BindingDB P10275

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.848 0.004 0.892 0.004 0.870 0.000 0.865 0.005 0.940 0.000 0.736 0.005 Download
Estate fingerprints 0.847 0.005 0.815 0.000 0.831 0.003 0.831 0.003 0.910 0.000 0.669 0.003 Download
MACCS fingerprints 0.823 0.005 0.797 0.000 0.810 0.000 0.810 0.000 0.880 0.000 0.617 0.005 Download
Daylight fingerprints 0.706 0.005 0.954 0.004 0.830 0.000 0.802 0.004 0.930 0.000 0.677 0.005 Download
ECFP2 fingerprints 0.920 0.000 0.940 0.000 0.930 0.000 0.930 0.000 0.980 0.000 0.863 0.005 Download
ECFP4 fingerprints 0.905 0.005 0.971 0.000 0.938 0.004 0.932 0.004 0.981 0.003 0.873 0.005 Download
ECFP6 fingerprints 0.892 0.004 0.968 0.005 0.930 0.000 0.930 0.000 0.980 0.000 0.865 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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