Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). Regulates expression of target genes in a ligand-dependent manner by recruiting chromatin complexes containing KMT2E/MLL5. Mediates retinoic acid-induced granulopoiesis.
Uniprot primary ID | P10276 |
PDB ID | 4DQM 3KMR 1DKF 3KMZ 3A9E 1DSZ |
DrugBank ID | DB00459 DB00799 DB00982 DB04942 DB00523 DB00210 |
BioGrid ID | 111849 |
GuidetoPHARMACOLOGY ID | 590 |
PharmGKB ID | PA34225 |
KEGG ID | hsa:5914 |
DIP ID | DIP-34N |
STRING ID | 9606.ENSP00000254066 |
IntAct ID | P10276 |
DMDM | 133483 |
BRENDA | |
Reactome | R-HSA-383280 R-HSA-5362517 |
SignaLink | P10276 |
BioCyc | |
Entrez Gene (Gene ID) | 5914 |
BindingDB | P10276 |
Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FP2 fingerprints | 0.937 | 0.007 | 0.961 | 0.003 | 0.949 | 0.003 | 0.949 | 0.003 | 0.990 | 0.000 | 0.900 | 0.005 | Download |
Estate fingerprints | 0.948 | 0.006 | 0.960 | 0.005 | 0.954 | 0.005 | 0.954 | 0.005 | 0.990 | 0.000 | 0.910 | 0.007 | Download |
MACCS fingerprints | 0.951 | 0.003 | 0.971 | 0.000 | 0.961 | 0.003 | 0.961 | 0.003 | 0.992 | 0.004 | 0.930 | 0.000 | Download |
Daylight fingerprints | 0.891 | 0.006 | 0.887 | 0.005 | 0.889 | 0.003 | 0.889 | 0.003 | 0.936 | 0.005 | 0.779 | 0.007 | Download |
ECFP2 fingerprints | 0.990 | 0.000 | 1.000 | 0.000 | 0.995 | 0.005 | 0.995 | 0.005 | 1.000 | 0.000 | 0.990 | 0.000 | Download |
ECFP4 fingerprints | 0.990 | 0.000 | 0.990 | 0.000 | 0.990 | 0.000 | 0.990 | 0.000 | 1.000 | 0.000 | 0.990 | 0.000 | Download |
ECFP6 fingerprints | 0.977 | 0.005 | 0.997 | 0.000 | 0.987 | 0.005 | 0.987 | 0.005 | 1.000 | 0.000 | 0.970 | 0.000 | Download |
Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn