Target name

P10276: Retinoic acid receptor alpha


  Protein function

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). Regulates expression of target genes in a ligand-dependent manner by recruiting chromatin complexes containing KMT2E/MLL5. Mediates retinoic acid-induced granulopoiesis.

  Database links

Uniprot primary ID P10276
PDB ID 4DQM 3KMR 1DKF 3KMZ 3A9E 1DSZ
DrugBank ID DB00459 DB00799 DB00982 DB04942 DB00523 DB00210
BioGrid ID 111849
GuidetoPHARMACOLOGY ID 590
PharmGKB ID PA34225
KEGG ID hsa:5914
DIP ID DIP-34N
STRING ID 9606.ENSP00000254066
IntAct ID P10276
DMDM 133483
BRENDA
Reactome R-HSA-383280 R-HSA-5362517
SignaLink P10276
BioCyc
Entrez Gene (Gene ID) 5914
BindingDB P10276

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.937 0.007 0.961 0.003 0.949 0.003 0.949 0.003 0.990 0.000 0.900 0.005 Download
Estate fingerprints 0.948 0.006 0.960 0.005 0.954 0.005 0.954 0.005 0.990 0.000 0.910 0.007 Download
MACCS fingerprints 0.951 0.003 0.971 0.000 0.961 0.003 0.961 0.003 0.992 0.004 0.930 0.000 Download
Daylight fingerprints 0.891 0.006 0.887 0.005 0.889 0.003 0.889 0.003 0.936 0.005 0.779 0.007 Download
ECFP2 fingerprints 0.990 0.000 1.000 0.000 0.995 0.005 0.995 0.005 1.000 0.000 0.990 0.000 Download
ECFP4 fingerprints 0.990 0.000 0.990 0.000 0.990 0.000 0.990 0.000 1.000 0.000 0.990 0.000 Download
ECFP6 fingerprints 0.977 0.005 0.997 0.000 0.987 0.005 0.987 0.005 1.000 0.000 0.970 0.000 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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