Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).
| Uniprot primary ID | P10415 |
| PDB ID | 4IEH 5AGW 4AQ3 2O2F 5AGX 4LVT 1GJH 2W3L 1G5M 1YSW 2XA0 4LXD 4MAN 2O22 2O21 |
| DrugBank ID | DB01050 DB01229 DB01248 DB01367 |
| BioGrid ID | 107068 |
| GuidetoPHARMACOLOGY ID | 2844 |
| PharmGKB ID | PA25302 |
| KEGG ID | hsa:596 |
| DIP ID | DIP-1043N |
| STRING ID | 9606.ENSP00000329623 |
| IntAct ID | P10415 |
| DMDM | 231632 |
| BRENDA | |
| Reactome | R-HSA-111447 R-HSA-844455 R-HSA-111453 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 596 |
| BindingDB | P10415 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.657 | 0.005 | 0.961 | 0.005 | 0.809 | 0.003 | 0.771 | 0.003 | 0.859 | 0.003 | 0.645 | 0.005 | Download |
| Estate fingerprints | 0.660 | 0.005 | 0.770 | 0.005 | 0.715 | 0.007 | 0.699 | 0.006 | 0.787 | 0.005 | 0.432 | 0.011 | Download |
| MACCS fingerprints | 0.530 | 0.000 | 0.830 | 0.000 | 0.680 | 0.000 | 0.620 | 0.000 | 0.770 | 0.000 | 0.371 | 0.003 | Download |
| Daylight fingerprints | 0.714 | 0.005 | 0.778 | 0.005 | 0.746 | 0.005 | 0.737 | 0.005 | 0.779 | 0.003 | 0.494 | 0.005 | Download |
| ECFP2 fingerprints | 0.738 | 0.010 | 0.948 | 0.005 | 0.843 | 0.005 | 0.823 | 0.007 | 0.924 | 0.005 | 0.699 | 0.009 | Download |
| ECFP4 fingerprints | 0.737 | 0.005 | 0.983 | 0.000 | 0.860 | 0.000 | 0.839 | 0.003 | 0.932 | 0.004 | 0.743 | 0.005 | Download |
| ECFP6 fingerprints | 0.668 | 0.009 | 0.994 | 0.007 | 0.831 | 0.006 | 0.798 | 0.004 | 0.940 | 0.000 | 0.701 | 0.006 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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