Target name

P10415: Apoptosis regulator Bcl-2


  Protein function

Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).

  Database links

Uniprot primary ID P10415
PDB ID 4IEH 5AGW 4AQ3 2O2F 5AGX 4LVT 1GJH 2W3L 1G5M 1YSW 2XA0 4LXD 4MAN 2O22 2O21
DrugBank ID DB01050 DB01229 DB01248 DB01367
BioGrid ID 107068
GuidetoPHARMACOLOGY ID 2844
PharmGKB ID PA25302
KEGG ID hsa:596
DIP ID DIP-1043N
STRING ID 9606.ENSP00000329623
IntAct ID P10415
DMDM 231632
BRENDA
Reactome R-HSA-111447 R-HSA-844455 R-HSA-111453
SignaLink
BioCyc
Entrez Gene (Gene ID) 596
BindingDB P10415

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.657 0.005 0.961 0.005 0.809 0.003 0.771 0.003 0.859 0.003 0.645 0.005 Download
Estate fingerprints 0.660 0.005 0.770 0.005 0.715 0.007 0.699 0.006 0.787 0.005 0.432 0.011 Download
MACCS fingerprints 0.530 0.000 0.830 0.000 0.680 0.000 0.620 0.000 0.770 0.000 0.371 0.003 Download
Daylight fingerprints 0.714 0.005 0.778 0.005 0.746 0.005 0.737 0.005 0.779 0.003 0.494 0.005 Download
ECFP2 fingerprints 0.738 0.010 0.948 0.005 0.843 0.005 0.823 0.007 0.924 0.005 0.699 0.009 Download
ECFP4 fingerprints 0.737 0.005 0.983 0.000 0.860 0.000 0.839 0.003 0.932 0.004 0.743 0.005 Download
ECFP6 fingerprints 0.668 0.009 0.994 0.007 0.831 0.006 0.798 0.004 0.940 0.000 0.701 0.006 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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