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E-mail: biomed@csu.edu.cn
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Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function.
| Uniprot primary ID | P10826 |
| PDB ID | 1HRA 4DM6 4JYG 4DM8 1XAP 4JYI 4JYH |
| DrugBank ID | DB00523 DB00459 DB00210 DB00799 DB04942 |
| BioGrid ID | 111850 |
| GuidetoPHARMACOLOGY ID | 591 |
| PharmGKB ID | PA34226 |
| KEGG ID | hsa:5915 |
| DIP ID | |
| STRING ID | 9606.ENSP00000332296 |
| IntAct ID | P10826 |
| DMDM | 17380507 |
| BRENDA | |
| Reactome | R-HSA-383280 R-HSA-5362517 |
| SignaLink | P10826 |
| BioCyc | |
| Entrez Gene (Gene ID) | 5915 |
| BindingDB | P10826 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.940 | 0.008 | 0.958 | 0.005 | 0.949 | 0.003 | 0.949 | 0.003 | 0.990 | 0.000 | 0.900 | 0.007 | Download |
| Estate fingerprints | 0.947 | 0.005 | 0.927 | 0.005 | 0.937 | 0.005 | 0.938 | 0.004 | 0.990 | 0.000 | 0.873 | 0.007 | Download |
| MACCS fingerprints | 0.930 | 0.000 | 0.982 | 0.000 | 0.956 | 0.005 | 0.950 | 0.000 | 0.990 | 0.000 | 0.910 | 0.000 | Download |
| Daylight fingerprints | 0.891 | 0.003 | 0.847 | 0.000 | 0.869 | 0.003 | 0.870 | 0.000 | 0.910 | 0.000 | 0.732 | 0.004 | Download |
| ECFP2 fingerprints | 0.992 | 0.004 | 0.998 | 0.000 | 0.995 | 0.005 | 0.995 | 0.005 | 1.000 | 0.000 | 0.989 | 0.006 | Download |
| ECFP4 fingerprints | 1.000 | 0.000 | 1.000 | 0.000 | 1.000 | 0.000 | 1.000 | 0.000 | 1.000 | 0.000 | 1.000 | 0.000 | Download |
| ECFP6 fingerprints | 0.990 | 0.000 | 1.000 | 0.000 | 0.998 | 0.004 | 0.998 | 0.004 | 1.000 | 0.000 | 0.990 | 0.000 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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