Target name

P10826: Retinoic acid receptor beta


  Protein function

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function.

  Database links

Uniprot primary ID P10826
PDB ID 1HRA 4DM6 4JYG 4DM8 1XAP 4JYI 4JYH
DrugBank ID DB00523 DB00459 DB00210 DB00799 DB04942
BioGrid ID 111850
GuidetoPHARMACOLOGY ID 591
PharmGKB ID PA34226
KEGG ID hsa:5915
DIP ID
STRING ID 9606.ENSP00000332296
IntAct ID P10826
DMDM 17380507
BRENDA
Reactome R-HSA-383280 R-HSA-5362517
SignaLink P10826
BioCyc
Entrez Gene (Gene ID) 5915
BindingDB P10826

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.940 0.008 0.958 0.005 0.949 0.003 0.949 0.003 0.990 0.000 0.900 0.007 Download
Estate fingerprints 0.947 0.005 0.927 0.005 0.937 0.005 0.938 0.004 0.990 0.000 0.873 0.007 Download
MACCS fingerprints 0.930 0.000 0.982 0.000 0.956 0.005 0.950 0.000 0.990 0.000 0.910 0.000 Download
Daylight fingerprints 0.891 0.003 0.847 0.000 0.869 0.003 0.870 0.000 0.910 0.000 0.732 0.004 Download
ECFP2 fingerprints 0.992 0.004 0.998 0.000 0.995 0.005 0.995 0.005 1.000 0.000 0.989 0.006 Download
ECFP4 fingerprints 1.000 0.000 1.000 0.000 1.000 0.000 1.000 0.000 1.000 0.000 1.000 0.000 Download
ECFP6 fingerprints 0.990 0.000 1.000 0.000 0.998 0.004 0.998 0.004 1.000 0.000 0.990 0.000 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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