TargetNet
  Target name

P10827: Thyroid hormone receptor alpha

  Protein function

Isoform Alpha-1: Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.

  Database links
Uniprot primary ID P10827
PDB ID 4LNX 4LNW 3ILZ 3JZB 1NAV 2H77 3HZF 2H79
DrugBank ID DB00509 DB00451 DB01583 DB00279
BioGrid ID 112923
GuidetoPHARMACOLOGY ID 588
PharmGKB ID PA36507
KEGG ID hsa:7067
DIP ID DIP-31452N
STRING ID 9606.ENSP00000264637
IntAct ID P10827
DMDM 135705
BRENDA
Reactome R-HSA-383280
SignaLink P10827
BioCyc
Entrez Gene (Gene ID) 7067
BindingDB P10827
  Model Performance Metrics
Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.893 0.005 0.907 0.003 0.900 0.000 0.900 0.000 0.960 0.000 0.803 0.005 Download
Estate fingerprints 0.846 0.007 0.802 0.004 0.824 0.005 0.826 0.005 0.926 0.005 0.649 0.009 Download
MACCS fingerprints 0.849 0.003 0.851 0.005 0.850 0.000 0.850 0.000 0.920 0.000 0.701 0.003 Download
Daylight fingerprints 0.818 0.004 0.822 0.000 0.820 0.000 0.820 0.000 0.840 0.000 0.638 0.004 Download
ECFP2 fingerprints 0.958 0.004 0.942 0.005 0.950 0.000 0.950 0.000 0.990 0.000 0.901 0.006 Download
ECFP4 fingerprints 0.989 0.003 0.971 0.003 0.980 0.000 0.980 0.000 1.000 0.000 0.961 0.003 Download
ECFP6 fingerprints 0.988 0.004 0.992 0.005 0.990 0.000 0.990 0.000 1.000 0.000 0.980 0.005 Download
  Download datasets
Positive dataset Negative dataset

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 E-mail: biomed@csu.edu.cn