Details-Calcnet-TargetNet

Target name

P10828: Thyroid hormone receptor beta

Protein function

Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.

Database links

Uniprot primary ID	P10828
PDB ID	4ZO1 1N46 1NQ2 2J4A 1NQ0 1NQ1 1BSX 1Q4X 1NUO 3JZC 1XZX 3GWS 3D57 1Y0X 2NLL 2PIN 1R6G 3IMY 1NAX
DrugBank ID	DB00509 DB00451 DB01583 DB00279
BioGrid ID	112924
GuidetoPHARMACOLOGY ID	589
PharmGKB ID	PA36508
KEGG ID	hsa:7068
DIP ID	DIP-5991N
STRING ID	9606.ENSP00000348827
IntAct ID	P10828
DMDM	586092
BRENDA
Reactome	R-HSA-383280
SignaLink	P10828
BioCyc
Entrez Gene (Gene ID)	7068
BindingDB	P10828

Model Performance Metrics

Fingerprint type	Sensitivity	SEN_std	Specificity	SPE_std	Accuracy	ACC_std	F1-score	F1-score_std	AUC	AUC_std	MCC	MCC_std	Download model
FP2 fingerprints	0.869	0.003	0.911	0.005	0.890	0.000	0.890	0.000	0.963	0.005	0.783	0.005	Download
Estate fingerprints	0.865	0.005	0.815	0.003	0.840	0.000	0.842	0.004	0.910	0.000	0.678	0.006	Download
MACCS fingerprints	0.808	0.004	0.846	0.005	0.827	0.005	0.826	0.005	0.900	0.000	0.658	0.008	Download
Daylight fingerprints	0.789	0.003	0.821	0.000	0.805	0.005	0.800	0.000	0.820	0.000	0.613	0.005	Download
ECFP2 fingerprints	0.950	0.005	0.938	0.006	0.944	0.005	0.944	0.005	0.990	0.000	0.887	0.005	Download
ECFP4 fingerprints	0.977	0.005	0.983	0.000	0.980	0.000	0.979	0.003	1.000	0.000	0.959	0.006	Download
ECFP6 fingerprints	0.971	0.006	0.987	0.000	0.979	0.003	0.979	0.003	1.000	0.000	0.961	0.006	Download

Download datasets

Positive dataset

Negative dataset