Target name

P10828: Thyroid hormone receptor beta


  Protein function

Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.

  Database links

Uniprot primary ID P10828
PDB ID 4ZO1 1N46 1NQ2 2J4A 1NQ0 1NQ1 1BSX 1Q4X 1NUO 3JZC 1XZX 3GWS 3D57 1Y0X 2NLL 2PIN 1R6G 3IMY 1NAX
DrugBank ID DB00509 DB00451 DB01583 DB00279
BioGrid ID 112924
GuidetoPHARMACOLOGY ID 589
PharmGKB ID PA36508
KEGG ID hsa:7068
DIP ID DIP-5991N
STRING ID 9606.ENSP00000348827
IntAct ID P10828
DMDM 586092
BRENDA
Reactome R-HSA-383280
SignaLink P10828
BioCyc
Entrez Gene (Gene ID) 7068
BindingDB P10828

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.869 0.003 0.911 0.005 0.890 0.000 0.890 0.000 0.963 0.005 0.783 0.005 Download
Estate fingerprints 0.865 0.005 0.815 0.003 0.840 0.000 0.842 0.004 0.910 0.000 0.678 0.006 Download
MACCS fingerprints 0.808 0.004 0.846 0.005 0.827 0.005 0.826 0.005 0.900 0.000 0.658 0.008 Download
Daylight fingerprints 0.789 0.003 0.821 0.000 0.805 0.005 0.800 0.000 0.820 0.000 0.613 0.005 Download
ECFP2 fingerprints 0.950 0.005 0.938 0.006 0.944 0.005 0.944 0.005 0.990 0.000 0.887 0.005 Download
ECFP4 fingerprints 0.977 0.005 0.983 0.000 0.980 0.000 0.979 0.003 1.000 0.000 0.959 0.006 Download
ECFP6 fingerprints 0.971 0.006 0.987 0.000 0.979 0.003 0.979 0.003 1.000 0.000 0.961 0.006 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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