The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol (By similarity).
| Uniprot primary ID | P10980 |
| PDB ID | |
| DrugBank ID | |
| BioGrid ID | |
| GuidetoPHARMACOLOGY ID | 14 |
| PharmGKB ID | |
| KEGG ID | rno:81645 |
| DIP ID | |
| STRING ID | 10116.ENSRNOP00000065178 |
| IntAct ID | |
| DMDM | |
| BRENDA | |
| Reactome | R-RNO-418594 R-RNO-390648 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 81645 |
| BindingDB | P10980 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.857 | 0.005 | 0.843 | 0.000 | 0.850 | 0.000 | 0.850 | 0.000 | 0.919 | 0.003 | 0.699 | 0.003 | Download |
| Estate fingerprints | 0.908 | 0.004 | 0.732 | 0.005 | 0.820 | 0.000 | 0.832 | 0.004 | 0.880 | 0.000 | 0.650 | 0.005 | Download |
| MACCS fingerprints | 0.809 | 0.006 | 0.731 | 0.004 | 0.770 | 0.000 | 0.779 | 0.003 | 0.870 | 0.000 | 0.540 | 0.005 | Download |
| Daylight fingerprints | 0.759 | 0.010 | 0.819 | 0.003 | 0.789 | 0.006 | 0.783 | 0.008 | 0.860 | 0.000 | 0.580 | 0.011 | Download |
| ECFP2 fingerprints | 0.906 | 0.005 | 0.892 | 0.005 | 0.899 | 0.003 | 0.899 | 0.003 | 0.970 | 0.000 | 0.793 | 0.005 | Download |
| ECFP4 fingerprints | 0.883 | 0.008 | 0.941 | 0.006 | 0.912 | 0.004 | 0.908 | 0.006 | 0.970 | 0.000 | 0.823 | 0.009 | Download |
| ECFP6 fingerprints | 0.847 | 0.005 | 0.969 | 0.005 | 0.908 | 0.004 | 0.901 | 0.003 | 0.969 | 0.003 | 0.820 | 0.007 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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