Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL (PubMed:3600759, PubMed:24293641). Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination (PubMed:17237796).
| Uniprot primary ID | P11597 |
| PDB ID | 4F2A 2OBD 4EWS |
| DrugBank ID | |
| BioGrid ID | 107498 |
| GuidetoPHARMACOLOGY ID | |
| PharmGKB ID | PA108 |
| KEGG ID | hsa:1071 |
| DIP ID | |
| STRING ID | 9606.ENSP00000200676 |
| IntAct ID | P11597 |
| DMDM | 71153497 |
| BRENDA | |
| Reactome | R-HSA-171052 R-HSA-194223 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 1071 |
| BindingDB | P11597 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.921 | 0.003 | 0.987 | 0.000 | 0.954 | 0.005 | 0.951 | 0.003 | 0.980 | 0.000 | 0.911 | 0.003 | Download |
| Estate fingerprints | 0.869 | 0.003 | 0.831 | 0.005 | 0.850 | 0.000 | 0.853 | 0.005 | 0.937 | 0.005 | 0.704 | 0.005 | Download |
| MACCS fingerprints | 0.869 | 0.003 | 0.851 | 0.005 | 0.860 | 0.000 | 0.861 | 0.003 | 0.939 | 0.003 | 0.721 | 0.007 | Download |
| Daylight fingerprints | 0.939 | 0.006 | 0.909 | 0.004 | 0.924 | 0.005 | 0.925 | 0.005 | 0.940 | 0.000 | 0.848 | 0.008 | Download |
| ECFP2 fingerprints | 0.960 | 0.000 | 0.978 | 0.003 | 0.969 | 0.003 | 0.968 | 0.004 | 0.983 | 0.005 | 0.930 | 0.000 | Download |
| ECFP4 fingerprints | 0.960 | 0.000 | 1.000 | 0.000 | 0.980 | 0.000 | 0.980 | 0.000 | 0.990 | 0.000 | 0.960 | 0.000 | Download |
| ECFP6 fingerprints | 0.952 | 0.004 | 0.998 | 0.000 | 0.975 | 0.005 | 0.972 | 0.004 | 0.990 | 0.000 | 0.950 | 0.000 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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