Target name

P11597: Cholesteryl ester transfer protein


  Protein function

Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL (PubMed:3600759, PubMed:24293641). Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination (PubMed:17237796).

  Database links

Uniprot primary ID P11597
PDB ID 4F2A 2OBD 4EWS
DrugBank ID
BioGrid ID 107498
GuidetoPHARMACOLOGY ID
PharmGKB ID PA108
KEGG ID hsa:1071
DIP ID
STRING ID 9606.ENSP00000200676
IntAct ID P11597
DMDM 71153497
BRENDA
Reactome R-HSA-171052 R-HSA-194223
SignaLink
BioCyc
Entrez Gene (Gene ID) 1071
BindingDB P11597

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.921 0.003 0.987 0.000 0.954 0.005 0.951 0.003 0.980 0.000 0.911 0.003 Download
Estate fingerprints 0.869 0.003 0.831 0.005 0.850 0.000 0.853 0.005 0.937 0.005 0.704 0.005 Download
MACCS fingerprints 0.869 0.003 0.851 0.005 0.860 0.000 0.861 0.003 0.939 0.003 0.721 0.007 Download
Daylight fingerprints 0.939 0.006 0.909 0.004 0.924 0.005 0.925 0.005 0.940 0.000 0.848 0.008 Download
ECFP2 fingerprints 0.960 0.000 0.978 0.003 0.969 0.003 0.968 0.004 0.983 0.005 0.930 0.000 Download
ECFP4 fingerprints 0.960 0.000 1.000 0.000 0.980 0.000 0.980 0.000 0.990 0.000 0.960 0.000 Download
ECFP6 fingerprints 0.952 0.004 0.998 0.000 0.975 0.005 0.972 0.004 0.990 0.000 0.950 0.000 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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