Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan.
Uniprot primary ID | P11712 |
PDB ID | 1OG5 4NZ2 1R9O 1OG2 |
DrugBank ID | DB01418 DB00898 DB00678 DB04574 DB01411 DB00891 DB00672 |
BioGrid ID | 107937 |
GuidetoPHARMACOLOGY ID | |
PharmGKB ID | PA126 |
KEGG ID | hsa:1559 |
DIP ID | |
STRING ID | 9606.ENSP00000260682 |
IntAct ID | P11712 |
DMDM | 6686268 |
BRENDA | 1.14.99.38 |
Reactome | R-HSA-211999 R-HSA-211981 R-HSA-2142670 R-HSA-2142816 |
SignaLink | |
BioCyc | |
Entrez Gene (Gene ID) | 1559 |
BindingDB | P11712 |
Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FP2 fingerprints | 0.704 | 0.008 | 0.702 | 0.007 | 0.703 | 0.005 | 0.703 | 0.005 | 0.769 | 0.003 | 0.406 | 0.008 | Download |
Estate fingerprints | 0.709 | 0.003 | 0.595 | 0.005 | 0.652 | 0.004 | 0.671 | 0.003 | 0.700 | 0.000 | 0.305 | 0.005 | Download |
MACCS fingerprints | 0.666 | 0.005 | 0.626 | 0.006 | 0.646 | 0.005 | 0.653 | 0.005 | 0.693 | 0.005 | 0.292 | 0.006 | Download |
Daylight fingerprints | 0.658 | 0.004 | 0.582 | 0.006 | 0.620 | 0.000 | 0.632 | 0.004 | 0.670 | 0.000 | 0.239 | 0.007 | Download |
ECFP2 fingerprints | 0.799 | 0.007 | 0.693 | 0.008 | 0.746 | 0.005 | 0.758 | 0.004 | 0.840 | 0.000 | 0.494 | 0.008 | Download |
ECFP4 fingerprints | 0.735 | 0.005 | 0.809 | 0.006 | 0.772 | 0.004 | 0.763 | 0.005 | 0.857 | 0.005 | 0.548 | 0.008 | Download |
ECFP6 fingerprints | 0.700 | 0.007 | 0.842 | 0.007 | 0.771 | 0.006 | 0.753 | 0.005 | 0.853 | 0.005 | 0.547 | 0.009 | Download |
Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn