Target name

P11802: Cyclin-dependent kinase 4


  Protein function

Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.

  Database links

Uniprot primary ID P11802
PDB ID 3G33 2W9F 2W9Z 2W99 2W96 1LD2
DrugBank ID DB09073
BioGrid ID 107454
GuidetoPHARMACOLOGY ID 1976
PharmGKB ID PA102
KEGG ID hsa:1019
DIP ID DIP-875N
STRING ID 9606.ENSP00000257904
IntAct ID P11802
DMDM 1168867
BRENDA 2.7.11.22
Reactome R-HSA-2559585 R-HSA-2559580 R-HSA-2559582 R-HSA-381340 R-HSA-912446 R-HSA-69231 R-HSA-3214858 R-HSA-69229
SignaLink P11802
BioCyc
Entrez Gene (Gene ID) 1019
BindingDB P11802

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.875 0.005 0.875 0.004 0.875 0.005 0.875 0.005 0.950 0.000 0.746 0.005 Download
Estate fingerprints 0.807 0.005 0.729 0.003 0.768 0.004 0.778 0.004 0.840 0.000 0.535 0.005 Download
MACCS fingerprints 0.860 0.000 0.720 0.005 0.790 0.000 0.807 0.005 0.871 0.003 0.590 0.000 Download
Daylight fingerprints 0.819 0.003 0.741 0.003 0.780 0.000 0.790 0.000 0.830 0.000 0.561 0.003 Download
ECFP2 fingerprints 0.969 0.003 0.891 0.000 0.930 0.000 0.933 0.005 0.980 0.000 0.865 0.005 Download
ECFP4 fingerprints 0.931 0.003 0.971 0.003 0.951 0.003 0.951 0.003 0.990 0.000 0.908 0.004 Download
ECFP6 fingerprints 0.894 0.005 0.986 0.003 0.940 0.000 0.940 0.000 0.989 0.003 0.884 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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