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E-mail: biomed@csu.edu.cn
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Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
| Uniprot primary ID | P11802 |
| PDB ID | 3G33 2W9F 2W9Z 2W99 2W96 1LD2 |
| DrugBank ID | DB09073 |
| BioGrid ID | 107454 |
| GuidetoPHARMACOLOGY ID | 1976 |
| PharmGKB ID | PA102 |
| KEGG ID | hsa:1019 |
| DIP ID | DIP-875N |
| STRING ID | 9606.ENSP00000257904 |
| IntAct ID | P11802 |
| DMDM | 1168867 |
| BRENDA | 2.7.11.22 |
| Reactome | R-HSA-2559585 R-HSA-2559580 R-HSA-2559582 R-HSA-381340 R-HSA-912446 R-HSA-69231 R-HSA-3214858 R-HSA-69229 |
| SignaLink | P11802 |
| BioCyc | |
| Entrez Gene (Gene ID) | 1019 |
| BindingDB | P11802 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.875 | 0.005 | 0.875 | 0.004 | 0.875 | 0.005 | 0.875 | 0.005 | 0.950 | 0.000 | 0.746 | 0.005 | Download |
| Estate fingerprints | 0.807 | 0.005 | 0.729 | 0.003 | 0.768 | 0.004 | 0.778 | 0.004 | 0.840 | 0.000 | 0.535 | 0.005 | Download |
| MACCS fingerprints | 0.860 | 0.000 | 0.720 | 0.005 | 0.790 | 0.000 | 0.807 | 0.005 | 0.871 | 0.003 | 0.590 | 0.000 | Download |
| Daylight fingerprints | 0.819 | 0.003 | 0.741 | 0.003 | 0.780 | 0.000 | 0.790 | 0.000 | 0.830 | 0.000 | 0.561 | 0.003 | Download |
| ECFP2 fingerprints | 0.969 | 0.003 | 0.891 | 0.000 | 0.930 | 0.000 | 0.933 | 0.005 | 0.980 | 0.000 | 0.865 | 0.005 | Download |
| ECFP4 fingerprints | 0.931 | 0.003 | 0.971 | 0.003 | 0.951 | 0.003 | 0.951 | 0.003 | 0.990 | 0.000 | 0.908 | 0.004 | Download |
| ECFP6 fingerprints | 0.894 | 0.005 | 0.986 | 0.003 | 0.940 | 0.000 | 0.940 | 0.000 | 0.989 | 0.003 | 0.884 | 0.005 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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