Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes.
| Uniprot primary ID | P12527 |
| PDB ID | |
| DrugBank ID | |
| BioGrid ID | |
| GuidetoPHARMACOLOGY ID | |
| PharmGKB ID | |
| KEGG ID | rno:25290 |
| DIP ID | DIP-48659N |
| STRING ID | 10116.ENSRNOP00000017633 |
| IntAct ID | |
| DMDM | |
| BRENDA | 1.13.11.34 |
| Reactome | |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 25290 |
| BindingDB | P12527 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.854 | 0.005 | 0.844 | 0.004 | 0.849 | 0.003 | 0.849 | 0.003 | 0.929 | 0.003 | 0.700 | 0.007 | Download |
| Estate fingerprints | 0.794 | 0.005 | 0.788 | 0.003 | 0.791 | 0.003 | 0.792 | 0.004 | 0.860 | 0.000 | 0.586 | 0.005 | Download |
| MACCS fingerprints | 0.797 | 0.005 | 0.843 | 0.003 | 0.820 | 0.000 | 0.810 | 0.000 | 0.900 | 0.000 | 0.636 | 0.005 | Download |
| Daylight fingerprints | 0.670 | 0.000 | 0.810 | 0.000 | 0.740 | 0.000 | 0.720 | 0.000 | 0.770 | 0.000 | 0.488 | 0.004 | Download |
| ECFP2 fingerprints | 0.940 | 0.000 | 0.900 | 0.005 | 0.920 | 0.000 | 0.920 | 0.000 | 0.973 | 0.005 | 0.839 | 0.003 | Download |
| ECFP4 fingerprints | 0.943 | 0.005 | 0.937 | 0.005 | 0.940 | 0.000 | 0.940 | 0.000 | 0.980 | 0.000 | 0.881 | 0.003 | Download |
| ECFP6 fingerprints | 0.933 | 0.005 | 0.929 | 0.000 | 0.931 | 0.003 | 0.931 | 0.003 | 0.980 | 0.000 | 0.866 | 0.005 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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