Target name

P12527: Arachidonate 5-lipoxygenase


  Protein function

Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes.

  Database links

Uniprot primary ID P12527
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID
PharmGKB ID
KEGG ID rno:25290
DIP ID DIP-48659N
STRING ID 10116.ENSRNOP00000017633
IntAct ID
DMDM
BRENDA 1.13.11.34
Reactome
SignaLink
BioCyc
Entrez Gene (Gene ID) 25290
BindingDB P12527

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.854 0.005 0.844 0.004 0.849 0.003 0.849 0.003 0.929 0.003 0.700 0.007 Download
Estate fingerprints 0.794 0.005 0.788 0.003 0.791 0.003 0.792 0.004 0.860 0.000 0.586 0.005 Download
MACCS fingerprints 0.797 0.005 0.843 0.003 0.820 0.000 0.810 0.000 0.900 0.000 0.636 0.005 Download
Daylight fingerprints 0.670 0.000 0.810 0.000 0.740 0.000 0.720 0.000 0.770 0.000 0.488 0.004 Download
ECFP2 fingerprints 0.940 0.000 0.900 0.005 0.920 0.000 0.920 0.000 0.973 0.005 0.839 0.003 Download
ECFP4 fingerprints 0.943 0.005 0.937 0.005 0.940 0.000 0.940 0.000 0.980 0.000 0.881 0.003 Download
ECFP6 fingerprints 0.933 0.005 0.929 0.000 0.931 0.003 0.931 0.003 0.980 0.000 0.866 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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