Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety.
| Uniprot primary ID | P12821 |
| PDB ID | 1O8A 3NXQ 4BXK 2C6N 2OC2 4BZR 4BZS 2C6F 1UZF 4APJ 2XYD 4C2O 3L3N 2YDM 3BKK 2IUX 3BKL 4C2N 2IUL 4C2Q 4C2P 4C2R 1UZE 4CA5 4CA6 2XY9 1O86 4APH |
| DrugBank ID | DB00691 DB01180 DB01348 DB01197 DB00492 DB00722 DB00584 |
| BioGrid ID | 108004 |
| GuidetoPHARMACOLOGY ID | 1613 |
| PharmGKB ID | PA139 |
| KEGG ID | hsa:1636 |
| DIP ID | |
| STRING ID | 9606.ENSP00000290866 |
| IntAct ID | P12821 |
| DMDM | 113045 |
| BRENDA | 3.4.15.1 |
| Reactome | R-HSA-2022377 |
| SignaLink | P12821 |
| BioCyc | MetaCyc:HS08412-MONOMER |
| Entrez Gene (Gene ID) | 1636 |
| BindingDB | P12821 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.931 | 0.003 | 0.949 | 0.005 | 0.940 | 0.000 | 0.939 | 0.003 | 0.980 | 0.000 | 0.876 | 0.005 | Download |
| Estate fingerprints | 0.933 | 0.005 | 0.923 | 0.005 | 0.928 | 0.004 | 0.928 | 0.004 | 0.980 | 0.000 | 0.850 | 0.000 | Download |
| MACCS fingerprints | 0.940 | 0.000 | 0.940 | 0.000 | 0.940 | 0.000 | 0.940 | 0.000 | 0.980 | 0.000 | 0.881 | 0.003 | Download |
| Daylight fingerprints | 0.864 | 0.007 | 0.808 | 0.000 | 0.836 | 0.005 | 0.839 | 0.003 | 0.860 | 0.000 | 0.667 | 0.005 | Download |
| ECFP2 fingerprints | 0.970 | 0.000 | 0.950 | 0.000 | 0.960 | 0.000 | 0.961 | 0.003 | 0.990 | 0.000 | 0.926 | 0.005 | Download |
| ECFP4 fingerprints | 0.979 | 0.003 | 0.961 | 0.005 | 0.970 | 0.000 | 0.970 | 0.000 | 0.990 | 0.000 | 0.937 | 0.005 | Download |
| ECFP6 fingerprints | 0.975 | 0.005 | 0.967 | 0.000 | 0.971 | 0.003 | 0.971 | 0.003 | 0.990 | 0.000 | 0.948 | 0.004 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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