Target name

P12821: Angiotensin-converting enzyme


  Protein function

Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety.

  Database links

Uniprot primary ID P12821
PDB ID 1O8A 3NXQ 4BXK 2C6N 2OC2 4BZR 4BZS 2C6F 1UZF 4APJ 2XYD 4C2O 3L3N 2YDM 3BKK 2IUX 3BKL 4C2N 2IUL 4C2Q 4C2P 4C2R 1UZE 4CA5 4CA6 2XY9 1O86 4APH
DrugBank ID DB00691 DB01180 DB01348 DB01197 DB00492 DB00722 DB00584
BioGrid ID 108004
GuidetoPHARMACOLOGY ID 1613
PharmGKB ID PA139
KEGG ID hsa:1636
DIP ID
STRING ID 9606.ENSP00000290866
IntAct ID P12821
DMDM 113045
BRENDA 3.4.15.1
Reactome R-HSA-2022377
SignaLink P12821
BioCyc MetaCyc:HS08412-MONOMER
Entrez Gene (Gene ID) 1636
BindingDB P12821

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.931 0.003 0.949 0.005 0.940 0.000 0.939 0.003 0.980 0.000 0.876 0.005 Download
Estate fingerprints 0.933 0.005 0.923 0.005 0.928 0.004 0.928 0.004 0.980 0.000 0.850 0.000 Download
MACCS fingerprints 0.940 0.000 0.940 0.000 0.940 0.000 0.940 0.000 0.980 0.000 0.881 0.003 Download
Daylight fingerprints 0.864 0.007 0.808 0.000 0.836 0.005 0.839 0.003 0.860 0.000 0.667 0.005 Download
ECFP2 fingerprints 0.970 0.000 0.950 0.000 0.960 0.000 0.961 0.003 0.990 0.000 0.926 0.005 Download
ECFP4 fingerprints 0.979 0.003 0.961 0.005 0.970 0.000 0.970 0.000 0.990 0.000 0.937 0.005 Download
ECFP6 fingerprints 0.975 0.005 0.967 0.000 0.971 0.003 0.971 0.003 0.990 0.000 0.948 0.004 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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