Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity).
| Uniprot primary ID | P12822 |
| PDB ID | |
| DrugBank ID | |
| BioGrid ID | |
| GuidetoPHARMACOLOGY ID | |
| PharmGKB ID | |
| KEGG ID | ocu:100009274 |
| DIP ID | |
| STRING ID | 9986.ENSOCUP00000016378 |
| IntAct ID | |
| DMDM | |
| BRENDA | |
| Reactome | |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 100009274 |
| BindingDB | P12822 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.970 | 0.000 | 0.922 | 0.008 | 0.946 | 0.005 | 0.949 | 0.003 | 0.974 | 0.007 | 0.897 | 0.009 | Download |
| Estate fingerprints | 0.969 | 0.003 | 0.841 | 0.006 | 0.905 | 0.005 | 0.913 | 0.005 | 0.957 | 0.005 | 0.823 | 0.007 | Download |
| MACCS fingerprints | 0.955 | 0.005 | 0.927 | 0.008 | 0.941 | 0.003 | 0.941 | 0.003 | 0.970 | 0.000 | 0.880 | 0.011 | Download |
| Daylight fingerprints | 0.960 | 0.005 | 0.864 | 0.011 | 0.912 | 0.006 | 0.916 | 0.007 | 0.949 | 0.007 | 0.828 | 0.012 | Download |
| ECFP2 fingerprints | 0.969 | 0.003 | 0.933 | 0.011 | 0.951 | 0.007 | 0.953 | 0.005 | 0.980 | 0.000 | 0.902 | 0.008 | Download |
| ECFP4 fingerprints | 0.969 | 0.003 | 0.949 | 0.005 | 0.959 | 0.003 | 0.959 | 0.003 | 0.986 | 0.005 | 0.914 | 0.007 | Download |
| ECFP6 fingerprints | 0.970 | 0.000 | 0.962 | 0.008 | 0.966 | 0.005 | 0.966 | 0.005 | 0.995 | 0.005 | 0.929 | 0.009 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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