Details-Calcnet-TargetNet

Target name

P12822: Angiotensin-converting enzyme

Protein function

Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity).

Database links

Uniprot primary ID	P12822
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID
PharmGKB ID
KEGG ID	ocu:100009274
DIP ID
STRING ID	9986.ENSOCUP00000016378
IntAct ID
DMDM
BRENDA
Reactome
SignaLink
BioCyc
Entrez Gene (Gene ID)	100009274
BindingDB	P12822

Model Performance Metrics

Fingerprint type	Sensitivity	SEN_std	Specificity	SPE_std	Accuracy	ACC_std	F1-score	F1-score_std	AUC	AUC_std	MCC	MCC_std	Download model
FP2 fingerprints	0.970	0.000	0.922	0.008	0.946	0.005	0.949	0.003	0.974	0.007	0.897	0.009	Download
Estate fingerprints	0.969	0.003	0.841	0.006	0.905	0.005	0.913	0.005	0.957	0.005	0.823	0.007	Download
MACCS fingerprints	0.955	0.005	0.927	0.008	0.941	0.003	0.941	0.003	0.970	0.000	0.880	0.011	Download
Daylight fingerprints	0.960	0.005	0.864	0.011	0.912	0.006	0.916	0.007	0.949	0.007	0.828	0.012	Download
ECFP2 fingerprints	0.969	0.003	0.933	0.011	0.951	0.007	0.953	0.005	0.980	0.000	0.902	0.008	Download
ECFP4 fingerprints	0.969	0.003	0.949	0.005	0.959	0.003	0.959	0.003	0.986	0.005	0.914	0.007	Download
ECFP6 fingerprints	0.970	0.000	0.962	0.008	0.966	0.005	0.966	0.005	0.995	0.005	0.929	0.009	Download

Download datasets

Positive dataset

Negative dataset