Target name

P12822: Angiotensin-converting enzyme


  Protein function

Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity).

  Database links

Uniprot primary ID P12822
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID
PharmGKB ID
KEGG ID ocu:100009274
DIP ID
STRING ID 9986.ENSOCUP00000016378
IntAct ID
DMDM
BRENDA
Reactome
SignaLink
BioCyc
Entrez Gene (Gene ID) 100009274
BindingDB P12822

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.970 0.000 0.922 0.008 0.946 0.005 0.949 0.003 0.974 0.007 0.897 0.009 Download
Estate fingerprints 0.969 0.003 0.841 0.006 0.905 0.005 0.913 0.005 0.957 0.005 0.823 0.007 Download
MACCS fingerprints 0.955 0.005 0.927 0.008 0.941 0.003 0.941 0.003 0.970 0.000 0.880 0.011 Download
Daylight fingerprints 0.960 0.005 0.864 0.011 0.912 0.006 0.916 0.007 0.949 0.007 0.828 0.012 Download
ECFP2 fingerprints 0.969 0.003 0.933 0.011 0.951 0.007 0.953 0.005 0.980 0.000 0.902 0.008 Download
ECFP4 fingerprints 0.969 0.003 0.949 0.005 0.959 0.003 0.959 0.003 0.986 0.005 0.914 0.007 Download
ECFP6 fingerprints 0.970 0.000 0.962 0.008 0.966 0.005 0.966 0.005 0.995 0.005 0.929 0.009 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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