Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells.
| Uniprot primary ID | P13612 |
| PDB ID | 3V4V 4HKC 3V4P |
| DrugBank ID | DB09033 DB06822 DB00108 |
| BioGrid ID | 109883 |
| GuidetoPHARMACOLOGY ID | 2443 |
| PharmGKB ID | PA29940 |
| KEGG ID | hsa:3676 |
| DIP ID | DIP-34971N |
| STRING ID | 9606.ENSP00000380227 |
| IntAct ID | P13612 |
| DMDM | 311033436 |
| BRENDA | |
| Reactome | R-HSA-216083 R-HSA-198933 R-HSA-202733 |
| SignaLink | P13612 |
| BioCyc | |
| Entrez Gene (Gene ID) | 3676 |
| BindingDB | P13612 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.940 | 0.000 | 0.930 | 0.000 | 0.935 | 0.005 | 0.935 | 0.005 | 0.970 | 0.000 | 0.869 | 0.003 | Download |
| Estate fingerprints | 0.930 | 0.000 | 0.850 | 0.003 | 0.890 | 0.000 | 0.892 | 0.004 | 0.950 | 0.000 | 0.781 | 0.003 | Download |
| MACCS fingerprints | 0.970 | 0.000 | 0.888 | 0.005 | 0.929 | 0.003 | 0.930 | 0.000 | 0.970 | 0.000 | 0.859 | 0.003 | Download |
| Daylight fingerprints | 0.900 | 0.000 | 0.940 | 0.005 | 0.920 | 0.000 | 0.920 | 0.000 | 0.940 | 0.000 | 0.850 | 0.000 | Download |
| ECFP2 fingerprints | 0.970 | 0.000 | 0.960 | 0.004 | 0.965 | 0.005 | 0.965 | 0.005 | 0.980 | 0.000 | 0.930 | 0.000 | Download |
| ECFP4 fingerprints | 0.970 | 0.000 | 0.978 | 0.000 | 0.974 | 0.005 | 0.974 | 0.005 | 0.989 | 0.003 | 0.950 | 0.000 | Download |
| ECFP6 fingerprints | 0.960 | 0.000 | 1.000 | 0.000 | 0.980 | 0.000 | 0.980 | 0.000 | 0.990 | 0.000 | 0.952 | 0.004 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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