Target name

P13612: Integrin alpha-4


  Protein function

Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells.

  Database links

Uniprot primary ID P13612
PDB ID 3V4V 4HKC 3V4P
DrugBank ID DB09033 DB06822 DB00108
BioGrid ID 109883
GuidetoPHARMACOLOGY ID 2443
PharmGKB ID PA29940
KEGG ID hsa:3676
DIP ID DIP-34971N
STRING ID 9606.ENSP00000380227
IntAct ID P13612
DMDM 311033436
BRENDA
Reactome R-HSA-216083 R-HSA-198933 R-HSA-202733
SignaLink P13612
BioCyc
Entrez Gene (Gene ID) 3676
BindingDB P13612

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.940 0.000 0.930 0.000 0.935 0.005 0.935 0.005 0.970 0.000 0.869 0.003 Download
Estate fingerprints 0.930 0.000 0.850 0.003 0.890 0.000 0.892 0.004 0.950 0.000 0.781 0.003 Download
MACCS fingerprints 0.970 0.000 0.888 0.005 0.929 0.003 0.930 0.000 0.970 0.000 0.859 0.003 Download
Daylight fingerprints 0.900 0.000 0.940 0.005 0.920 0.000 0.920 0.000 0.940 0.000 0.850 0.000 Download
ECFP2 fingerprints 0.970 0.000 0.960 0.004 0.965 0.005 0.965 0.005 0.980 0.000 0.930 0.000 Download
ECFP4 fingerprints 0.970 0.000 0.978 0.000 0.974 0.005 0.974 0.005 0.989 0.003 0.950 0.000 Download
ECFP6 fingerprints 0.960 0.000 1.000 0.000 0.980 0.000 0.980 0.000 0.990 0.000 0.952 0.004 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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