Target name

P13631: Retinoic acid receptor gamma


  Protein function

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function (By similarity).

  Database links

Uniprot primary ID P13631
PDB ID 2LBD 1FD0 1FCX 1FCY 1FCZ 1EXA 1EXX 4LBD 3LBD
DrugBank ID DB00799 DB00523 DB00459 DB00755 DB00210
BioGrid ID 111851
GuidetoPHARMACOLOGY ID 592
PharmGKB ID PA34227
KEGG ID hsa:5916
DIP ID
STRING ID 9606.ENSP00000377947
IntAct ID P13631
DMDM 133498
BRENDA
Reactome R-HSA-383280 R-HSA-5362517
SignaLink P13631
BioCyc
Entrez Gene (Gene ID) 5916
BindingDB P13631

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.932 0.004 0.940 0.000 0.936 0.005 0.936 0.005 0.980 0.000 0.872 0.004 Download
Estate fingerprints 0.940 0.000 0.960 0.005 0.950 0.000 0.949 0.003 0.990 0.000 0.899 0.003 Download
MACCS fingerprints 0.940 0.000 0.956 0.000 0.948 0.004 0.940 0.000 0.980 0.000 0.888 0.004 Download
Daylight fingerprints 0.901 0.003 0.859 0.000 0.880 0.000 0.880 0.000 0.920 0.000 0.756 0.007 Download
ECFP2 fingerprints 0.978 0.004 0.992 0.005 0.985 0.005 0.985 0.005 1.000 0.000 0.966 0.007 Download
ECFP4 fingerprints 0.980 0.000 1.000 0.004 0.990 0.000 0.990 0.000 1.000 0.000 0.976 0.005 Download
ECFP6 fingerprints 0.977 0.005 1.000 0.003 0.990 0.000 0.990 0.000 1.000 0.000 0.976 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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