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Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function (By similarity).
| Uniprot primary ID | P13631 |
| PDB ID | 2LBD 1FD0 1FCX 1FCY 1FCZ 1EXA 1EXX 4LBD 3LBD |
| DrugBank ID | DB00799 DB00523 DB00459 DB00755 DB00210 |
| BioGrid ID | 111851 |
| GuidetoPHARMACOLOGY ID | 592 |
| PharmGKB ID | PA34227 |
| KEGG ID | hsa:5916 |
| DIP ID | |
| STRING ID | 9606.ENSP00000377947 |
| IntAct ID | P13631 |
| DMDM | 133498 |
| BRENDA | |
| Reactome | R-HSA-383280 R-HSA-5362517 |
| SignaLink | P13631 |
| BioCyc | |
| Entrez Gene (Gene ID) | 5916 |
| BindingDB | P13631 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.932 | 0.004 | 0.940 | 0.000 | 0.936 | 0.005 | 0.936 | 0.005 | 0.980 | 0.000 | 0.872 | 0.004 | Download |
| Estate fingerprints | 0.940 | 0.000 | 0.960 | 0.005 | 0.950 | 0.000 | 0.949 | 0.003 | 0.990 | 0.000 | 0.899 | 0.003 | Download |
| MACCS fingerprints | 0.940 | 0.000 | 0.956 | 0.000 | 0.948 | 0.004 | 0.940 | 0.000 | 0.980 | 0.000 | 0.888 | 0.004 | Download |
| Daylight fingerprints | 0.901 | 0.003 | 0.859 | 0.000 | 0.880 | 0.000 | 0.880 | 0.000 | 0.920 | 0.000 | 0.756 | 0.007 | Download |
| ECFP2 fingerprints | 0.978 | 0.004 | 0.992 | 0.005 | 0.985 | 0.005 | 0.985 | 0.005 | 1.000 | 0.000 | 0.966 | 0.007 | Download |
| ECFP4 fingerprints | 0.980 | 0.000 | 1.000 | 0.004 | 0.990 | 0.000 | 0.990 | 0.000 | 1.000 | 0.000 | 0.976 | 0.005 | Download |
| ECFP6 fingerprints | 0.977 | 0.005 | 1.000 | 0.003 | 0.990 | 0.000 | 0.990 | 0.000 | 1.000 | 0.000 | 0.976 | 0.005 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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