Target name

P13726: Tissue factor


  Protein function

Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.

  Database links

Uniprot primary ID P13726
PDB ID 2PUQ 1WUN 1WQV 1DAN 2B8O 1WSS 3ELA 2ZWL 2HFT 3TH4 2CEH 1O5D 1JPS 2ZP0 1AHW 2CEF 2CEZ 1TFH 1WV7 1W2K 4M7L 1Z6J 1WTG 2AEI 1J9C 2C4F 2AER 2F9B 2B7D 2FLR 2CFJ 1W0Y 2ZZU 1NL8 2FIR 2A2Q 2FLB 2EC9 1FAK 1BOY 3TH3 3TH2 1UJ3 4IBL
DrugBank ID DB00036
BioGrid ID 108451
GuidetoPHARMACOLOGY ID
PharmGKB ID PA158
KEGG ID hsa:2152
DIP ID DIP-6136N
STRING ID 9606.ENSP00000334145
IntAct ID P13726
DMDM 135666
BRENDA
Reactome R-HSA-140834
SignaLink
BioCyc
Entrez Gene (Gene ID) 2152
BindingDB P13726

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.894 0.017 0.984 0.000 0.939 0.010 0.937 0.008 0.980 0.000 0.885 0.015 Download
Estate fingerprints 0.858 0.004 0.904 0.012 0.881 0.006 0.878 0.006 0.940 0.000 0.763 0.013 Download
MACCS fingerprints 0.768 0.004 0.910 0.011 0.839 0.006 0.826 0.005 0.933 0.005 0.687 0.012 Download
Daylight fingerprints 0.857 0.027 1.000 0.000 0.929 0.011 0.923 0.014 0.970 0.000 0.866 0.020 Download
ECFP2 fingerprints 0.863 0.007 0.957 0.005 0.910 0.005 0.905 0.005 0.971 0.003 0.823 0.009 Download
ECFP4 fingerprints 0.946 0.013 0.986 0.000 0.966 0.005 0.966 0.005 0.985 0.005 0.933 0.013 Download
ECFP6 fingerprints 0.934 0.012 0.988 0.000 0.961 0.006 0.961 0.006 0.986 0.005 0.924 0.012 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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