Target name

P13866: Sodium/glucose cotransporter 1


  Protein function

Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules.

  Database links

Uniprot primary ID P13866
PDB ID
DrugBank ID DB08907
BioGrid ID 112414
GuidetoPHARMACOLOGY ID 915
PharmGKB ID PA308
KEGG ID hsa:6523
DIP ID
STRING ID 9606.ENSP00000266088
IntAct ID P13866
DMDM 127803
BRENDA
Reactome R-HSA-189200 R-HSA-428808 R-HSA-429593
SignaLink
BioCyc
Entrez Gene (Gene ID) 6523
BindingDB P13866

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.866 0.007 0.992 0.000 0.929 0.003 0.927 0.005 0.985 0.005 0.867 0.005 Download
Estate fingerprints 0.848 0.008 0.910 0.003 0.879 0.003 0.878 0.004 0.930 0.000 0.760 0.005 Download
MACCS fingerprints 0.870 0.000 0.956 0.005 0.913 0.005 0.910 0.000 0.957 0.005 0.833 0.005 Download
Daylight fingerprints 0.872 0.004 0.988 0.000 0.930 0.000 0.926 0.005 0.960 0.000 0.866 0.005 Download
ECFP2 fingerprints 0.936 0.007 0.986 0.000 0.961 0.003 0.959 0.003 0.990 0.000 0.922 0.006 Download
ECFP4 fingerprints 0.966 0.007 0.992 0.003 0.979 0.003 0.979 0.003 0.991 0.003 0.963 0.009 Download
ECFP6 fingerprints 0.949 0.003 0.997 0.000 0.973 0.005 0.970 0.000 0.998 0.004 0.949 0.003 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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