Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH.
| Uniprot primary ID | P14061 |
| PDB ID | 1QYX 3KM0 1IOL 1QYW 1JTV 3DHE 1FDU 1FDT 1FDW 1FDV 1BHS 3KLM 1EQU 3DEY 3KLP 1A27 1QYV 3HB5 3HB4 1FDS 1I5R 1DHT |
| DrugBank ID | DB02187 |
| BioGrid ID | 109525 |
| GuidetoPHARMACOLOGY ID | |
| PharmGKB ID | PA29478 |
| KEGG ID | hsa:3292 |
| DIP ID | |
| STRING ID | 9606.ENSP00000466799 |
| IntAct ID | |
| DMDM | 313104233 |
| BRENDA | 1.1.1.62 |
| Reactome | R-HSA-193144 R-HSA-2453902 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 3292 |
| BindingDB | P14061 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.974 | 0.005 | 0.926 | 0.000 | 0.950 | 0.000 | 0.950 | 0.000 | 0.990 | 0.000 | 0.904 | 0.005 | Download |
| Estate fingerprints | 0.881 | 0.017 | 0.845 | 0.007 | 0.863 | 0.009 | 0.865 | 0.010 | 0.920 | 0.000 | 0.723 | 0.019 | Download |
| MACCS fingerprints | 0.904 | 0.005 | 0.904 | 0.000 | 0.904 | 0.005 | 0.904 | 0.005 | 0.953 | 0.005 | 0.808 | 0.011 | Download |
| Daylight fingerprints | 0.889 | 0.012 | 0.853 | 0.004 | 0.871 | 0.009 | 0.871 | 0.009 | 0.911 | 0.003 | 0.740 | 0.013 | Download |
| ECFP2 fingerprints | 0.990 | 0.000 | 0.916 | 0.009 | 0.953 | 0.005 | 0.953 | 0.005 | 0.990 | 0.000 | 0.906 | 0.008 | Download |
| ECFP4 fingerprints | 0.990 | 0.000 | 0.968 | 0.003 | 0.979 | 0.003 | 0.979 | 0.003 | 1.000 | 0.000 | 0.950 | 0.000 | Download |
| ECFP6 fingerprints | 0.989 | 0.003 | 0.967 | 0.003 | 0.978 | 0.004 | 0.978 | 0.004 | 1.000 | 0.000 | 0.950 | 0.000 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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