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E-mail: biomed@csu.edu.cn
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Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.
| Uniprot primary ID | P14174 |
| PDB ID | 4GRO 4GRN 3L5R 3L5S 3L5P 3L5V 3L5T 3L5U 1LJT 3JTU 4EUI 4GRU 3DJI 3DJH 4GRQ 4GRP 4GRR 1CA7 4WR8 1P1G 3IJG 3B9S 4P0H 4K9G 1MIF 3JSF 3JSG 2OOH 3IJJ 3U18 4GUM 4P01 3CE4 2OOZ 4EVG 3WNS 1GD0 1GIF 4ETG 2OOW 1GCZ 3WNT 1CGQ 4WRB 4OYQ 3HOF 3WNR 4F2K 4OSF 3SMC 3SMB |
| DrugBank ID | |
| BioGrid ID | 110428 |
| GuidetoPHARMACOLOGY ID | |
| PharmGKB ID | PA30819 |
| KEGG ID | hsa:4282 |
| DIP ID | DIP-31137N |
| STRING ID | 9606.ENSP00000215754 |
| IntAct ID | P14174 |
| DMDM | 1170955 |
| BRENDA | 5.3.3.12 5.3.2.1 |
| Reactome | |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 4282 |
| BindingDB | P14174 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.872 | 0.006 | 0.928 | 0.011 | 0.900 | 0.007 | 0.897 | 0.005 | 0.967 | 0.005 | 0.805 | 0.013 | Download |
| Estate fingerprints | 0.939 | 0.006 | 0.895 | 0.016 | 0.917 | 0.008 | 0.918 | 0.006 | 0.977 | 0.005 | 0.831 | 0.012 | Download |
| MACCS fingerprints | 0.929 | 0.007 | 0.883 | 0.006 | 0.906 | 0.005 | 0.906 | 0.005 | 0.970 | 0.000 | 0.815 | 0.005 | Download |
| Daylight fingerprints | 0.781 | 0.014 | 0.827 | 0.005 | 0.804 | 0.007 | 0.799 | 0.009 | 0.860 | 0.000 | 0.605 | 0.011 | Download |
| ECFP2 fingerprints | 0.944 | 0.007 | 0.882 | 0.010 | 0.913 | 0.007 | 0.915 | 0.005 | 0.982 | 0.004 | 0.829 | 0.011 | Download |
| ECFP4 fingerprints | 0.941 | 0.003 | 0.873 | 0.014 | 0.907 | 0.008 | 0.910 | 0.008 | 0.980 | 0.000 | 0.819 | 0.016 | Download |
| ECFP6 fingerprints | 0.919 | 0.011 | 0.883 | 0.011 | 0.901 | 0.007 | 0.901 | 0.007 | 0.970 | 0.000 | 0.806 | 0.013 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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