Target name

P14174: Macrophage migration inhibitory factor


  Protein function

Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.

  Database links

Uniprot primary ID P14174
PDB ID 4GRO 4GRN 3L5R 3L5S 3L5P 3L5V 3L5T 3L5U 1LJT 3JTU 4EUI 4GRU 3DJI 3DJH 4GRQ 4GRP 4GRR 1CA7 4WR8 1P1G 3IJG 3B9S 4P0H 4K9G 1MIF 3JSF 3JSG 2OOH 3IJJ 3U18 4GUM 4P01 3CE4 2OOZ 4EVG 3WNS 1GD0 1GIF 4ETG 2OOW 1GCZ 3WNT 1CGQ 4WRB 4OYQ 3HOF 3WNR 4F2K 4OSF 3SMC 3SMB
DrugBank ID
BioGrid ID 110428
GuidetoPHARMACOLOGY ID
PharmGKB ID PA30819
KEGG ID hsa:4282
DIP ID DIP-31137N
STRING ID 9606.ENSP00000215754
IntAct ID P14174
DMDM 1170955
BRENDA 5.3.3.12 5.3.2.1
Reactome
SignaLink
BioCyc
Entrez Gene (Gene ID) 4282
BindingDB P14174

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.872 0.006 0.928 0.011 0.900 0.007 0.897 0.005 0.967 0.005 0.805 0.013 Download
Estate fingerprints 0.939 0.006 0.895 0.016 0.917 0.008 0.918 0.006 0.977 0.005 0.831 0.012 Download
MACCS fingerprints 0.929 0.007 0.883 0.006 0.906 0.005 0.906 0.005 0.970 0.000 0.815 0.005 Download
Daylight fingerprints 0.781 0.014 0.827 0.005 0.804 0.007 0.799 0.009 0.860 0.000 0.605 0.011 Download
ECFP2 fingerprints 0.944 0.007 0.882 0.010 0.913 0.007 0.915 0.005 0.982 0.004 0.829 0.011 Download
ECFP4 fingerprints 0.941 0.003 0.873 0.014 0.907 0.008 0.910 0.008 0.980 0.000 0.819 0.016 Download
ECFP6 fingerprints 0.919 0.011 0.883 0.011 0.901 0.007 0.901 0.007 0.970 0.000 0.806 0.013 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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