Target name

P14324: Farnesyl pyrophosphate synthase


  Protein function

Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.

  Database links

Uniprot primary ID P14324
PDB ID 2OPN 2RAH 2F8Z 4GA3 4N1Z 4KFA 4KQ5 1ZW5 3N6K 4L2X 1YQ7 2F8C 2VF6 4LPG 4H5C 2F94 4LPH 2F92 4P0V 4P0W 3S4J 4KPJ 4JVJ 3N5J 4NKF 4NKE 3B7L 4KPD 4P0X 2QIS 3N46 4Q23 4PVX 4PVY 3N1V 3N1W 2F7M 2F9K 2OPM 4H5E 4H5D 3N5H 4NFI 4NFJ 4NFK 4NG6 3N45 4OGU 4QPF 4DEM 2F89
DrugBank ID DB00399 DB00884 DB00630 DB00710 DB00282
BioGrid ID 108517
GuidetoPHARMACOLOGY ID 644
PharmGKB ID PA28075
KEGG ID hsa:2224
DIP ID DIP-50059N
STRING ID 9606.ENSP00000349078
IntAct ID P14324
DMDM 215274250
BRENDA 2.5.1.10
Reactome R-HSA-191273 R-HSA-2426168
SignaLink
BioCyc MetaCyc:ENSG00000160752-MONOMER
Entrez Gene (Gene ID) 2224
BindingDB P14324

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.960 0.000 1.000 0.000 0.980 0.000 0.980 0.000 0.980 0.000 0.960 0.000 Download
Estate fingerprints 0.960 0.000 0.980 0.000 0.970 0.000 0.970 0.000 0.990 0.000 0.940 0.000 Download
MACCS fingerprints 0.960 0.000 0.990 0.005 0.975 0.005 0.970 0.000 0.991 0.003 0.945 0.005 Download
Daylight fingerprints 0.844 0.005 0.876 0.000 0.860 0.000 0.860 0.000 0.900 0.000 0.714 0.005 Download
ECFP2 fingerprints 0.960 0.000 1.000 0.000 0.980 0.000 0.980 0.000 0.990 0.000 0.960 0.000 Download
ECFP4 fingerprints 0.960 0.000 1.000 0.000 0.980 0.000 0.972 0.004 0.990 0.000 0.952 0.004 Download
ECFP6 fingerprints 0.970 0.000 0.970 0.005 0.970 0.000 0.970 0.000 0.990 0.000 0.937 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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