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E-mail: biomed@csu.edu.cn
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Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
| Uniprot primary ID | P14324 |
| PDB ID | 2OPN 2RAH 2F8Z 4GA3 4N1Z 4KFA 4KQ5 1ZW5 3N6K 4L2X 1YQ7 2F8C 2VF6 4LPG 4H5C 2F94 4LPH 2F92 4P0V 4P0W 3S4J 4KPJ 4JVJ 3N5J 4NKF 4NKE 3B7L 4KPD 4P0X 2QIS 3N46 4Q23 4PVX 4PVY 3N1V 3N1W 2F7M 2F9K 2OPM 4H5E 4H5D 3N5H 4NFI 4NFJ 4NFK 4NG6 3N45 4OGU 4QPF 4DEM 2F89 |
| DrugBank ID | DB00399 DB00884 DB00630 DB00710 DB00282 |
| BioGrid ID | 108517 |
| GuidetoPHARMACOLOGY ID | 644 |
| PharmGKB ID | PA28075 |
| KEGG ID | hsa:2224 |
| DIP ID | DIP-50059N |
| STRING ID | 9606.ENSP00000349078 |
| IntAct ID | P14324 |
| DMDM | 215274250 |
| BRENDA | 2.5.1.10 |
| Reactome | R-HSA-191273 R-HSA-2426168 |
| SignaLink | |
| BioCyc | MetaCyc:ENSG00000160752-MONOMER |
| Entrez Gene (Gene ID) | 2224 |
| BindingDB | P14324 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.960 | 0.000 | 1.000 | 0.000 | 0.980 | 0.000 | 0.980 | 0.000 | 0.980 | 0.000 | 0.960 | 0.000 | Download |
| Estate fingerprints | 0.960 | 0.000 | 0.980 | 0.000 | 0.970 | 0.000 | 0.970 | 0.000 | 0.990 | 0.000 | 0.940 | 0.000 | Download |
| MACCS fingerprints | 0.960 | 0.000 | 0.990 | 0.005 | 0.975 | 0.005 | 0.970 | 0.000 | 0.991 | 0.003 | 0.945 | 0.005 | Download |
| Daylight fingerprints | 0.844 | 0.005 | 0.876 | 0.000 | 0.860 | 0.000 | 0.860 | 0.000 | 0.900 | 0.000 | 0.714 | 0.005 | Download |
| ECFP2 fingerprints | 0.960 | 0.000 | 1.000 | 0.000 | 0.980 | 0.000 | 0.980 | 0.000 | 0.990 | 0.000 | 0.960 | 0.000 | Download |
| ECFP4 fingerprints | 0.960 | 0.000 | 1.000 | 0.000 | 0.980 | 0.000 | 0.972 | 0.004 | 0.990 | 0.000 | 0.952 | 0.004 | Download |
| ECFP6 fingerprints | 0.970 | 0.000 | 0.970 | 0.005 | 0.970 | 0.000 | 0.970 | 0.000 | 0.990 | 0.000 | 0.937 | 0.005 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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