Target name

P14555: Phospholipase A2, membrane associated


  Protein function

Thought to participate in the regulation of the phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.

  Database links

Uniprot primary ID P14555
PDB ID 1DB5 1DB4 2GNY 1J1A 1POD 3U8H 1DCY 1KVO 3U8B 1POE 1BBC 1AYP 3U8I 1N28 3U8D 1N29 1KQU
DrugBank ID DB01381 DB04786 DB00328 DB00586
BioGrid ID 111337
GuidetoPHARMACOLOGY ID 1417
PharmGKB ID PA270
KEGG ID hsa:5320
DIP ID
STRING ID 9606.ENSP00000364252
IntAct ID P14555
DMDM 129483
BRENDA 3.1.1.4
Reactome R-HSA-1483166 R-HSA-1482839 R-HSA-1482801 R-HSA-1482925 R-HSA-1482922 R-HSA-1482788
SignaLink
BioCyc
Entrez Gene (Gene ID) 5320
BindingDB P14555

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.771 0.003 0.989 0.003 0.880 0.000 0.870 0.000 0.970 0.000 0.782 0.004 Download
Estate fingerprints 0.820 0.000 0.918 0.003 0.869 0.003 0.861 0.003 0.930 0.000 0.740 0.005 Download
MACCS fingerprints 0.852 0.008 0.916 0.006 0.884 0.005 0.877 0.007 0.960 0.000 0.765 0.011 Download
Daylight fingerprints 0.740 0.000 1.000 0.000 0.870 0.000 0.850 0.000 0.843 0.005 0.760 0.000 Download
ECFP2 fingerprints 0.891 0.003 0.973 0.005 0.932 0.004 0.931 0.003 0.987 0.005 0.868 0.006 Download
ECFP4 fingerprints 0.930 0.000 0.990 0.000 0.960 0.000 0.960 0.000 0.990 0.000 0.921 0.003 Download
ECFP6 fingerprints 0.910 0.000 1.000 0.000 0.958 0.004 0.955 0.005 0.990 0.000 0.915 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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