This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K.
| Uniprot primary ID | P14600 |
| PDB ID | |
| DrugBank ID | |
| BioGrid ID | 246930 |
| GuidetoPHARMACOLOGY ID | 360 |
| PharmGKB ID | |
| KEGG ID | rno:24807 |
| DIP ID | |
| STRING ID | 10116.ENSRNOP00000007984 |
| IntAct ID | |
| DMDM | |
| BRENDA | |
| Reactome | R-RNO-380095 R-RNO-416476 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 24807 |
| BindingDB | P14600 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.899 | 0.013 | 0.873 | 0.008 | 0.886 | 0.008 | 0.888 | 0.009 | 0.948 | 0.004 | 0.773 | 0.014 | Download |
| Estate fingerprints | 0.788 | 0.013 | 0.756 | 0.012 | 0.772 | 0.009 | 0.774 | 0.011 | 0.857 | 0.005 | 0.542 | 0.020 | Download |
| MACCS fingerprints | 0.787 | 0.008 | 0.753 | 0.011 | 0.770 | 0.008 | 0.772 | 0.009 | 0.875 | 0.005 | 0.539 | 0.017 | Download |
| Daylight fingerprints | 0.742 | 0.010 | 0.828 | 0.006 | 0.785 | 0.007 | 0.777 | 0.008 | 0.829 | 0.003 | 0.576 | 0.012 | Download |
| ECFP2 fingerprints | 0.892 | 0.006 | 0.920 | 0.006 | 0.906 | 0.005 | 0.906 | 0.005 | 0.958 | 0.004 | 0.815 | 0.007 | Download |
| ECFP4 fingerprints | 0.813 | 0.007 | 0.937 | 0.003 | 0.875 | 0.005 | 0.865 | 0.005 | 0.959 | 0.003 | 0.757 | 0.008 | Download |
| ECFP6 fingerprints | 0.750 | 0.008 | 0.938 | 0.000 | 0.844 | 0.005 | 0.829 | 0.006 | 0.952 | 0.004 | 0.703 | 0.007 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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