Target name

P14600: Substance-P receptor


  Protein function

This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K.

  Database links

Uniprot primary ID P14600
PDB ID
DrugBank ID
BioGrid ID 246930
GuidetoPHARMACOLOGY ID 360
PharmGKB ID
KEGG ID rno:24807
DIP ID
STRING ID 10116.ENSRNOP00000007984
IntAct ID
DMDM
BRENDA
Reactome R-RNO-380095 R-RNO-416476
SignaLink
BioCyc
Entrez Gene (Gene ID) 24807
BindingDB P14600

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.899 0.013 0.873 0.008 0.886 0.008 0.888 0.009 0.948 0.004 0.773 0.014 Download
Estate fingerprints 0.788 0.013 0.756 0.012 0.772 0.009 0.774 0.011 0.857 0.005 0.542 0.020 Download
MACCS fingerprints 0.787 0.008 0.753 0.011 0.770 0.008 0.772 0.009 0.875 0.005 0.539 0.017 Download
Daylight fingerprints 0.742 0.010 0.828 0.006 0.785 0.007 0.777 0.008 0.829 0.003 0.576 0.012 Download
ECFP2 fingerprints 0.892 0.006 0.920 0.006 0.906 0.005 0.906 0.005 0.958 0.004 0.815 0.007 Download
ECFP4 fingerprints 0.813 0.007 0.937 0.003 0.875 0.005 0.865 0.005 0.959 0.003 0.757 0.008 Download
ECFP6 fingerprints 0.750 0.008 0.938 0.000 0.844 0.005 0.829 0.006 0.952 0.004 0.703 0.007 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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