Target name

P14740: Dipeptidyl peptidase 4


  Protein function

Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.

  Database links

Uniprot primary ID P14740
PDB ID 4FFV 4FFW 2GBG 2GBF 2I3Z 2GBC 2GBI 2OAE
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID
PharmGKB ID
KEGG ID rno:25253
DIP ID
STRING ID 10116.ENSRNOP00000045536
IntAct ID P14740
DMDM
BRENDA 3.4.14.5
Reactome
SignaLink
BioCyc
Entrez Gene (Gene ID) 25253
BindingDB P14740

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.973 0.005 0.967 0.003 0.970 0.000 0.970 0.000 0.990 0.000 0.944 0.005 Download
Estate fingerprints 0.970 0.000 0.970 0.005 0.970 0.000 0.970 0.000 1.000 0.000 0.939 0.009 Download
MACCS fingerprints 0.970 0.005 0.990 0.004 0.980 0.000 0.980 0.000 1.000 0.000 0.959 0.003 Download
Daylight fingerprints 0.914 0.010 0.968 0.005 0.941 0.006 0.939 0.003 0.970 0.000 0.885 0.007 Download
ECFP2 fingerprints 0.950 0.000 0.990 0.005 0.970 0.000 0.970 0.000 1.000 0.000 0.946 0.005 Download
ECFP4 fingerprints 0.960 0.005 1.000 0.005 0.981 0.003 0.980 0.000 1.000 0.000 0.960 0.005 Download
ECFP6 fingerprints 0.957 0.007 0.999 0.007 0.978 0.004 0.978 0.004 1.000 0.000 0.957 0.007 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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